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Merck
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主要文件

250233

Sigma-Aldrich

Cytochalasin B

from Helminthosporium dematioideum, ≥98% (HPLC), solid, cell-permeable fungal toxin, Calbiochem®

别名:

细胞松弛素B，来源于长蠕孢菌

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About This Item

经验公式（希尔记法）:
C29H37NO5
CAS号:
14930-96-2
分子量:
479.61
MDL编号:
MFCD00077704
UNSPSC代码:
12352200
NACRES:
NA.77

产品名称

细胞松弛素B，来源于长蠕孢菌, Cell-permeable fungal toxin.

质量水平

100

描述

Merck USA index - 14, 2790

方案

≥98% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

white

溶解性

methanol: 20 mg/mL
DMSO: 50 mg/mL

运输

ambient

储存温度

−20°C

SMILES字符串

N1[C@H]([C@H]3[C@@]4(OC(=O)\C=C\[C@@H](CCC[C@H](C\C=C\[C@H]4[C@@H](C(=C)[C@H]3C)O)C)O)C1=O)Cc2ccccc2

InChI

1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1

InChI key

GBOGMAARMMDZGR-TYHYBEHESA-N

一般描述

细胞可透过性真菌毒素。通过阻止收缩性微丝的形成来抑制细胞质分裂。抑制细胞运动并诱导核挤压。通过阻止聚合物快速生长端的单体添加来缩短肌动蛋白丝。抑制葡萄糖转运和血小板聚集。阻断腺苷诱导的凋亡小体形成，而不影响白血病HL-60细胞内源性ADP核糖基化的激活。

生化/生理作用

主要目的
阻断收缩性微丝的形成
产品不与ATP竞争。
可逆：否
细胞渗透性：是

注意

劣质DMSO会导致产品降解，因此建议选用高质量的DMSO。

警告

毒性：&

重悬

复溶后，储存在冰箱中（4°C）。储备溶液在4°C下可稳定保存3个月。

其他说明

Tanaka, Y., et al. 1994.Exp.Cell Res. 213, 242.
Theodoropoulos, P.A., et al. 1994.生物化学。Pharmacol.47, 1875.
Benya, P.D., and Padilla, S.R.1993.Exp.Cell Res. 204, 268.
Cairns, M.T., et al. 1991.J. Biol. Chem.266, 8176.
Nowak, D. 1990.Biomed.Biochim.Acta49, 353.
Wang, F., et al. 1990.Biochem.Biophys.Res. Commun.171, 543.
Edwards, S.W., and Lloyd, D. 1988.FEBS Lett.227, 39.
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法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Repr. 2

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

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