203709

Insulin Expression Inducer, BRD7389

A cell-permeable naphthoquinolinedione compound that specifically induces insulin secretion in mouse αTC1-cells and promotes transdifferentiation to a β-cell-like status.

• 别名: Insulin Expression Inducer, BRD7389, 1-((2-Phenylethyl)amino)-3H-naphtho[1,2,3-de]quinoline-2,7-dione, Insulin Receptor-Related Protein Inhibitor, IRR Inhibitor, INSRR Inhibitor, RSK Inhibitor III
• 经验公式（希尔记法）: C₂₄H₁₈N₂O₂
• CAS号: 376382-11-5
• 分子量: 366.41
• MDL编号: MFCD02924820
• UNSPSC代码: 12352200
• NACRES: NA.51

属性

• 质量水平: 100
• 方案: ≥98% (HPLC)
• 表单: solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; protect from light
• 颜色: orange-yellow
• 溶解性: DMSO: 100 mg/mL
• 运输: ambient
• 储存温度: 2-8°C
• SMILES字符串: [nH]1c2c3c(c5c([c](c3ccc2)=O)cccc5)c([c]1=O)NCCc4ccccc4
• InChI: 1S/C24H18N2O2/c27-23-17-10-5-4-9-16(17)21-20-18(23)11-6-12-19(20)26-24(28)22(21)25-14-13-15-7-2-1-3-8-15/h1-12,25H,13-14H2,(H,26,28)
• InChI key: XASCINRGTHLHGM-UHFFFAOYSA-N

说明

一般描述

A cell-permeable naphthoquinolinedione compound that is reported to preferentially inhibit 23 kinases (IC₅₀ ≤10 µM) from a panel of 219, notably IRR (h), CLK2(h), Rsk1(h), Flt3(h), Rsk1(r), Rsk2(h), Haspin(h), Rsk4(h), Melk(h), Drak1(h), Rsk3(h), and CK13(h) (% inhibition by 10 µM BRD7389 = 91, 87, 86, 79, 78, 76, 74, 73, 73, 72, 71, and 71, respectively). Shown to induce β-cell-like morphology in cultured murine pancreatic α-cell αTC1 and stimulate the expression of insulin mRNA (by ~50-fold; 0.85 µM for 5 d) and protein (by 1.5-fold; 3.4 µM for 5 d), as well as other β-cell mRNAs, including Iapp, Npy, Pdx1, and Pax4, in αTC1 cultures. In human primary islets cultures, BRD7389 treatments result in a decrease of overall cell counts over time due to apoptosis induction, while insulin-positive population, and in some cases also glucagon-positive cell population, remains more or less unaffected.

包装

Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

重悬

Following recontitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Fomina-Yadlin, D., et al. 2010. Proc. Natl. Acad. Sci. USA107, 15099.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable