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BMS

Water-soluble reagent useful for the reduction of native disulfide bonds in proteins. Considered to be a superior reducing agent to DTT.

• 别名: BMS, bis(2-Mercaptoethylsulfone)
• 经验公式（希尔记法）: C₄H₁₀O₂S₃
• CAS号: 145626-87-5
• 分子量: 186.32
• MDL號碼: MFCD00467637
• 分類程式碼代碼: 12352128

属性

• 品質等級: 100
• 化驗: ≥99% (titration)
• 形狀: crystalline solid
• 反應適用性: reagent type: reductant
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: white
• pKa: (1) 7.9, (2) 9.0
• 運輸包裝: ambient
• 儲存溫度: −20°C
• SMILES 字串: [S](=O)(=O)(CCS)CCS
• InChI: 1S/C4H10O2S3/c5-9(6,3-1-7)4-2-8/h7-8H,1-4H2
• InChI 密鑰: YWXCBLUCVBSYNJ-UHFFFAOYSA-N

说明

一般說明

Water-soluble reagent useful for the reduction of native disulfide bonds in proteins. Considered to be a superior reducing agent to DTT. Shown to reduce accessible disulfide bonds in immunoglobulin and trypsinogen under non-denaturing conditions 5 to 7 times faster than DTT at pH 7. The relatively less accessible disulfide bond in α-chymotrypsinogen A was reduced 2.3 times faster at pH 7 with BMS than with DTT. Has a pK_a of 7.9 and 9.0.

Water-soluble reagent useful for the reduction of native disulfide bonds in proteins. Considered to be a superior reducing agent to DTT. Shown to reduce accessible disulfide bonds in immunoglobulin and trypsinogen under non-denaturing conditions 5 to 7 times faster than DTT at pH 7. The relatively less accessible disulfide bond in α-chymotrypsinogen A was reduced 2.3 times faster at with BMS than with DTT at pH 7.0.

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

準備報告

May require warming (40-45°C) to achieve complete solubilization in H₂O.

其他說明

Singh, R., et al. 1995. Methods Enzymol.251, 167.
Singh, R., and Whitesides, G.M. 1994. Bioorg. Chem.22, 109.
Singh, R., and Whitesides, G.M. 1994. Protein Sci. 3, Suppl. 1, 430T.
Lamoureux, G.V., and Whitesides, G.M. 1993. J. Org. Chem.58, 633.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable