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Merck
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Key Documents

20-247

Sigma-Aldrich

Peroxynitrite, degraded

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About This Item

分類程式碼代碼:
41116012
eCl@ss:
32160405
NACRES:
NA.42

形狀

liquid

品質等級

製造商/商標名

Upstate®

技術

nitration: suitable

運輸包裝

dry ice

應用

Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases

品質

Routinely evaluated by treatment of non-stimulated A431 cells with degraded peroxynitrite; subsequent lack of positive staining was detected with anti-nitrotyrosine antibody (06-284).

外觀

Degraded peroxynitrite (50-100mM); solution containing approximately 255mM H2O2, 0.18M NaOH, 0.23M NaCl, 23mM NaNO3 and 20mM NaNO2.

儲存和穩定性

1 year at -70°C

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

象形圖

Corrosion

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2

儲存類別代碼

5.1B - Oxidizing hazardous materials

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Oxidative chemistry of peroxynitrite.
Beckman, J S, et al.
Test, 233, 229-240 (1994)
Pathological implications of nitric oxide, superoxide and peroxynitrite formation.
Beckman, J S and Crow, J P
Biochemical Society Transactions, 21, 330-334 (1993)
James Murray et al.
The Journal of biological chemistry, 278(39), 37223-37230 (2003-07-15)
There is growing evidence that oxidative phosphorylation (OXPHOS) generates reactive oxygen and nitrogen species within mitochondria as unwanted byproducts that can damage OXPHOS enzymes with subsequent enhancement of free radical production. The accumulation of this oxidative damage to mitochondria in

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