149101-M

1-Aminocyclopropanecarboxylic acid

≥98% (TLC), crystalline solid, NMDA agonist, Calbiochem

• 别名: 1-Aminocyclopropane-1-carboxylic Acid, ACPC
• 经验公式（希尔记法）: C₄H₇NO₂
• CAS号: 22059-21-8
• 分子量: 101.10
• MDL號碼: MFCD00009944
• 分類程式碼代碼: 12352106
• NACRES: NA.77

属性

• product name: 1-Aminocyclopropane-1-carboxylic Acid, An agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex.
• 品質等級: 100
• 化驗: ≥98% (TLC)
• 形狀: crystalline solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 溶解度: water: 40 mg/mL
• 儲存溫度: 10-30°C
• InChI: 1S/C4H7NO2/c5-4(1-2-4)3(6)7/h1-2,5H2,(H,6,7)
• InChI 密鑰: PAJPWUMXBYXFCZ-UHFFFAOYSA-N

说明

一般說明

A potent and selective ligand for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Blocks ³H-glycine binding to rat forebrain membranes (IC₅₀ = 38 nM).

An agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Mimics the effects of glycine on the NMDA receptor ion channel and blocks ³H-glycine binding to rat forebrain membrane (IC₅₀ = 38 nM). Blocks NMDA-induced release of arachidonic acid (IC₅₀ = 131 µM) in cerebellar granule cells. Reduces NMDA-induced cell death in hippocampal neurons.

生化／生理作用

Primary Target
Glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex

Target IC₅₀: 38 nM in blocking 3H-glycine binding to rat forebrain membrane; 131 µM in blocking NMDA-induced release of arachidonic acid; 131 µM in cerebellar granule cells

警告

Toxicity: Irritant (B)

準備報告

May require heating and sonication to achieve complete solubilization.

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他說明

Viu, E., et al. 1998. J. Pharm. Exp. Ther.285, 527.
Zapata, A., et al. 1996. NeuroReport7, 397.
Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.
Rottmann, W.H., et al. 1991. J. Mol. Biol.222, 937.
Marvizon, J.C., et al. 1989. J. Neurochem.52, 992.
Nadler, V., et al. 1988. Eur. J. Pharmacol.157, 115.
Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA76, 170.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable