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Merck
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主要文件

12-439

Sigma-Aldrich

视网膜母细胞瘤蛋白(aa 773-928)

Recombinant fusion protein containing the C-terminal fragment (residues 773-928) of human retinoblastoma protein (Rb) with an N-terminal His6-tag, expressed in E. coli.

别名:

Rb Protein, Retinoblastoma Protein

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About This Item

UNSPSC代码:
12352202
eCl@ss:
32160405
NACRES:
NA.41

重组

expressed in E. coli

质量水平

表单

liquid

制造商/商品名称

Upstate®

浓度

2.0 mg/mL

技术

activity assay: suitable (kinase)

NCBI登记号

UniProt登记号

运输

dry ice

基因信息

human ... RB1(5925)

质量

常规评估为许多丝氨酸/苏氨酸激酶的底物。

外形

50 mM Tris-HCl(pH 7.5),150 mM NaCl和500 mM 咪唑

储存及稳定性

自收到之日起在-20°C可稳定保存1年。 分装保存以避免反复冻融。

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

象形图

Health hazardCorrosion

警示用语:

Danger

危险声明

危险分类

Eye Dam. 1 - Repr. 1B - Skin Corr. 1C

储存分类代码

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Despite the biological and therapeutic relevance of CDK4/6 for the treatment of HR+, HER2- advanced breast cancer, the detailed mode of action of CDK4/6 inhibitors is not completely understood. Of particular interest, phosphorylation of CDK4 at T172 (pT172) is critical
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Nature communications, 7, 11084-11084 (2016-03-31)
Cyclin-dependent kinases (CDKs) play key roles in cell cycle regulation. Genetic analysis in mice has revealed an essential role for Cdk2 in meiosis, which renders Cdk2 knockout (KO) mice sterile. Here we show that mice deficient in RingoA, an atypical
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Oncogene, 40(30), 4872-4883 (2021-06-24)
Cyclin D1 is an essential regulator of the G1-S cell-cycle transition and is overexpressed in many cancers. Expression of cyclin D1 is under tight cellular regulation that is controlled by many signaling pathways. Here we report that PARP14, a member

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