推荐产品
生物源
rabbit
品質等級
抗體表格
affinity purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
polyclonal
純化經由
affinity chromatography
物種活性
human
製造商／商標名
Upstate®
技術
western blot: suitable
同型
IgG
UniProt登錄號
運輸包裝
dry ice
目標翻譯後修改
phosphorylation (pThr34)
基因資訊
human ... AKT1(207)
特異性
Predicted to cross react with Mouse and Rat due to high sequence homology, but have not been tested.
Recognizes phospho-AKT (Thr34)
免疫原
KLH conjugated peptide corresponding to amino acid region encompassing the human phospho-AKT (Thr34); Sequence highly conserved in mouse and rat.
應用
Anti-phospho-AKT (Thr34) Antibody detects level of phospho-AKT (Thr34) & has been published & validated for use in WB.
Research Category
Signaling
Signaling
Research Sub Category
PI3K, Akt, & mTOR Signaling
General Post-translation Modification
PI3K, Akt, & mTOR Signaling
General Post-translation Modification
品質
Routinely evaluated by immunoblot.
標靶描述
60 kDa
外觀
ImmunoAffinity Purified
100 μL of epitope specific affinity purified rabbit polyclonal IgG in 50% affinity storage buffer (PBS containing 1.0 mg/mL BSA and 0.05% sodium azide) and 50% glycerol.
儲存和穩定性
Stable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
Cisplatin activates Akt in small cell lung cancer cells and attenuates apoptosis by survivin upregulation
Belyanskaya, Larisa L, et al
International Journal of Cancer. Journal International Du Cancer, 117, 755-763 (2005)
PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond.
Marte, B M and Downward, J
Trends in Biochemical Sciences, 22, 355-358 (1997)
Virginia Actis Dato et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 152, 113270-113270 (2022-06-17)
Antibodies against the P3 sequence (Gly1127-Cys1140) of LRP1 (anti-P3 Abs) specifically block cholesteryl ester (CE) accumulation in vascular cells. LRP1 is a key regulator of insulin receptor (InsR) trafficking in different cell types. The link between CE accumulation and the
Progesterone receptor enhances breast cancer cell motility and invasion via extranuclear activation of focal adhesion kinase.
Fu, XD; Goglia, L; Sanchez, AM; Flamini, M; Giretti, MS; Tosi, V; Genazzani, AR; Simoncini, T
Endocrine-Related Cancer null
Virginia Actis Dato et al.
Cells, 9(1) (2020-01-16)
Abstract: The cardiovascular disease (CVD) frequently developed during metabolic syndrome and type-2 diabetes mellitus is associated with increased levels of aggregation-prone small LDL particles. Aggregated LDL (aggLDL) internalization is mediated by low-density lipoprotein receptor-related protein-1 (LRP1) promoting intracellular cholesteryl ester
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