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品質等級
化驗
97%
形狀
liquid
折射率
n20/D 1.4713
bp
79-81 °C/13 mmHg (lit.)
密度
0.985 g/mL at 25 °C (lit.)
SMILES 字串
OCCN1CCCC1
InChI
1S/C6H13NO/c8-6-5-7-3-1-2-4-7/h8H,1-6H2
InChI 密鑰
XBRDBODLCHKXHI-UHFFFAOYSA-N
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European journal of drug metabolism and pharmacokinetics, 21(3), 261-268 (1996-07-01)
N-(2-hydroxyethyl)-pyrrolidine (HEP, Epolamine) is a strong base used to salify organic acids of pharmaceutical interest in order to improve their solubility in water. Diclofenac-HEP (Flector) is the first example of an epolamine salt of a drug. In this study, [14C]-HEP
Pharmaceutics, 4(3), 413-429 (2012-01-01)
The following bases: monoethylamine (EtA), diethylamine (DEtA), triethylamine (TEtA), monoethanolamine (MEA), diethanolamine (DEA), triethanolamine (TEA), pyrrolidine (Py), piperidine (Pp), morpholine (M), piperazine (Pz) and their N-2-hydroxyethyl (HE) analogs were employed to prepare 14 diclofenac salts. The salts were re-crystallized from
The Physician and sportsmedicine, 39(1), 11-18 (2011-03-08)
The diclofenac epolamine topical patch 1.3% (DETP) is indicated for topical treatment of acute pain due to minor strains, sprains, and contusions. This exploratory, multicenter, open-label study evaluated effectiveness and safety of DETP in patients with acute pain due to
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