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Merck

A8309

Sigma-Aldrich

乙酰肼

90%

别名:

Acetic acid hydrazide, Acetylhydrazine

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About This Item

线性分子式:
CH3CONHNH2
CAS号:
分子量:
74.08
Beilstein:
506165
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

化驗

90%

形狀

flakes

雜質

<10% acetic acid

bp

129 °C/18 mmHg (lit.)

mp

58-68 °C (lit.)

SMILES 字串

CC(=O)NN

InChI

1S/C2H6N2O/c1-2(5)4-3/h3H2,1H3,(H,4,5)

InChI 密鑰

OFLXLNCGODUUOT-UHFFFAOYSA-N

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一般說明

乙酰肼是一种有机合成砌块,可通过催化氢化反应生成 N′-甲基乙酰肼(MAH)。

應用

乙酰乙肼可用于合成(E)-N′-(2-羟基亚苄基)乙酰肼,这是一种 ONO 钳形配体。

象形圖

Skull and crossbonesHealth hazard

訊號詞

Danger

危險分類

Acute Tox. 3 Oral - Carc. 2 - Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 1

閃點(°F)

235.4 °F - closed cup

閃點(°C)

113 °C - closed cup

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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N E Preece et al.
Journal of chromatography, 573(2), 227-234 (1992-01-17)
Plasma and liver levels of hydrazine were determined at 10, 30, 90 and 270 min in rats given 0.09, 0.27, 0.84 and 2.53 mmol of hydrazine per kg body weight orally by capillary gas chromatography-mass spectrometry of its pentafluorobenzaldehyde adduct
Shahrzad Tafazoli et al.
Toxicology and applied pharmacology, 229(1), 94-101 (2008-02-26)
Isoniazid is an anti-tuberculosis drug that can cause hepatotoxicity in 20% of patients that is usually associated with an inflammatory response. Hepatocytes when exposed to non-toxic levels of H2O2, to simulate H2O2 formation by inflammatory cells, became twice as sensitive
D J Fort et al.
Teratogenesis, carcinogenesis, and mutagenesis, 10(6), 463-476 (1990-01-01)
The developmental toxicity of isoniazid (INH) and the metabolites acetylhydrazide (AH) and isonicotinic acid (INA) were examined with the frog embryo teratogenesis assay-Xenopus (FETAX). Late Xenopus laevis blastulae were exposed to INH, AH, and INA for 96 h in two
Victoria E Richards et al.
Toxicological sciences : an official journal of the Society of Toxicology, 82(1), 318-332 (2004-07-30)
Hydrazine (HD) and acetylhydrazine (AcHD) are metabolites of the antituberculosis drug isoniazid (INH) that have been implicated in INH-induced liver damage. The hepatotoxicity of AcHD and HD were compared in adult male C57Bl/6J mice by evaluating hepatic histopathology, plasma biochemistry
B K Sinha
Biochimica et biophysica acta, 924(2), 261-269 (1987-05-19)
Spin-trapping techniques and electron spin resonance spectroscopy have been used to study bioactivations of hydrazine and its derivatives by isolated perfused rat livers. Using phenylbutylnitrone (PBN) as the stable spin trap, it was found that the liver perfusion of hydrazine

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