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Different from common Poly(lactide-co-glycolide) (PLGA) polymer, the lactic and glycolic units in Poly(lactide-alt-glycolide) alternate in sequence in the polymer chain, and the molar ratio of lactic to glycolic units in the polymer is exactly 1:1. Poly(lactide-alt-glycolide) exhibits excellent solubility in common organic solvents, such as acetonitrile, acetone, dioxane, DCM, and THF, providing great convenience for drug delivery researches and applications.
Common Poly(lactide-co-glycolide) (PLGA) is a biocompatible and biodegradable polymer that has been approved by the FDA for biomedical and pharmaceutical applications. PLGA based polymers are usually synthesized from copolymerization of glycolide (GA) and lactide (LA). However, the copolymerization of glycolide (GA) and Lactide (LA) typically results in broad composition ranges and a random block nature because of the much higher reactivity of GA and the drastic polymerization conditions. Thus, simple use of equimolar charges of GA and LA results in polymers containing longer glycolic blocks leads to poor solubility in common solvents.
Common Poly(lactide-co-glycolide) (PLGA) is a biocompatible and biodegradable polymer that has been approved by the FDA for biomedical and pharmaceutical applications. PLGA based polymers are usually synthesized from copolymerization of glycolide (GA) and lactide (LA). However, the copolymerization of glycolide (GA) and Lactide (LA) typically results in broad composition ranges and a random block nature because of the much higher reactivity of GA and the drastic polymerization conditions. Thus, simple use of equimolar charges of GA and LA results in polymers containing longer glycolic blocks leads to poor solubility in common solvents.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Synthesis of poly(D,L-lactic acid-alt-glycolic acid) from D,L-3-methylglycolide
Dong C M, et al.
Journal of Polymer Science Part A: Polymer Chemistry, 38, 4179-4179 (2000)
Lin Yu et al.
Biomacromolecules, 12(4), 1290-1297 (2011-03-03)
This paper reports the influence of sequence structures of block copolymers composed of poly(lactic acid-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) on their thermogelling aqueous behaviors. A series of thermogelling PLGA-PEG-PLGA triblock copolymers with similar chemical compositions and block lengths
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