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Merck

55452

Sigma-Aldrich

D-α-羟基异戊酸

≥98.0% (T)

别名:

(R)-2-羟基-3-甲基丁酸

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About This Item

经验公式(希尔记法):
C5H10O3
CAS号:
分子量:
118.13
Beilstein:
1721139
MDL號碼:
分類程式碼代碼:
51113400
PubChem物質ID:
NACRES:
NA.22

化驗

≥98.0% (T)

形狀

solid

光學活性

[α]20/D −17±1°, c = 1% in chloroform

mp

64-67 °C

SMILES 字串

CC(C)[C@@H](O)C(O)=O

InChI

1S/C5H10O3/c1-3(2)4(6)5(7)8/h3-4,6H,1-2H3,(H,7,8)/t4-/m1/s1

InChI 密鑰

NGEWQZIDQIYUNV-SCSAIBSYSA-N

應用

D-α-Hydroxyisovaleric acid may be used in the preparation of biodegradable, optically active and isotactic poly(D-2-hydroxy-3-methylbutanoic acid).

其他說明

该手性 α-羟基酸用于合成肽和缩酚酸肽。 还可用作手性结构单元。 通过二氧戊环酮中间体合成 α-取代 α-羟基酸。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析证书(COA)

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R L Johnson
Journal of medicinal chemistry, 23(6), 666-669 (1980-06-01)
The following N-(alpha-hydroxylakanoyl) derivatives of Leu-Val-Phe-OCH3 were synthesized and tested for their ability to inhibit human amniotic renin: D- and L-alpha-hydroxyisocaproyl-Leu-Val-Phe-OCH3, D- and L-alpha-hydroxyisovaleryl-Leu-Val-Phe-OCH3, L-2-hydroxy-3-phenylpropanoyl-Leu-Val-Phe-OCH3, and D- and L-alpha-hydroxyphenylacetyl-Leu-Val-Phe-OCH3. Analysis of the compounds through the use of Dixion plots showed
H.-O. Kim et al.
The Journal of Organic Chemistry, 52, 4531-4531 (1987)
W. Hartwig et al.
Liebigs Ann. Chem., 1952-1952 (1982)
Hetero-stereocomplex formation between substituted poly (lactic acid) s with linear and branched side chains, poly (l-2-hydroxybutanoic acid) and poly (d-2-hydroxy-3-methylbutanoic acid).
Tsuji H and Hayakawa T.
Polymer, 55(3), 721-726 (2014)
Hye-Ran Yoon
Archives of pharmacal research, 30(3), 387-395 (2007-04-12)
A rapid dried-filter paper plasma-spot analytical method was developed to quantify organic acids, amino acids, and glycines simultaneously in a two-step derivatization procedure with good sensitivity and specificity. The new method involves a two-step trimethylsilyl (TMS) - trifluoroacyl (TFA) derivatization

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