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Merck
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文件

511943

Sigma-Aldrich

1-乙酰基-4-(4-羟基苯基)哌嗪

98%

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About This Item

经验公式（希尔记法）:
C12H16N2O2
CAS号:
67914-60-7
分子量:
220.27
EC號碼:
267-744-8
MDL號碼:
MFCD00044905
分類程式碼代碼:
12352100
PubChem物質ID:
24873593

化驗

98%

mp

180-185 °C (lit.)

SMILES 字串

CC(=O)N1CCN(CC1)c2ccc(O)cc2

InChI

1S/C12H16N2O2/c1-10(15)13-6-8-14(9-7-13)11-2-4-12(16)5-3-11/h2-5,16H,6-9H2,1H3

InChI 密鑰

AGVNLFCRZULMKK-UHFFFAOYSA-N

一般說明

1-Acetyl-4-(4-hydroxyphenyl)piperazine (AHPP), a piperazine derivative, is a structural analog of acetaminophen. Its multi-step preparation using bis-(2-chloroethyl)amine hydrochloride and p-aminophenol as starting materials has been reported.2

應用

1-Acetyl-4-(4-hydroxyphenyl)piperazine may be used in the preparation of 1-acetyl-4-(4-octadecyloxyphenyl)piperazine. It may also be used in the multi-step synthesis of ketoconazole, its 1,2,4-triazole and thiazole analogs.

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H315,H319,H335

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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1-Boc-哌嗪 97%

Sigma-Aldrich

343536

1-Boc-哌嗪

Synthesis of 1, 2,4-triazole and thiazole analogs of ketoconazole.
Huang LF, et al.
Journal of Heterocyclic Chemistry, 34(2), 469-476 (1997)
Design of new potent and selective secretory phospholipase A2 inhibitors. 6-Synthesis, structure-activity relationships and molecular modelling of 1-substituted-4-[4,5-dihydro-1,2,4-(4H)-oxadiazol-5-one-3-yl(methyl)]-functionalized aryl piperazin/one/dione derivatives.
Meddad-Belhabich N, et al.
Bioorganic & Medicinal Chemistry, 18(10), 3588-3600 (2010)
Synthesis of Ketoconazole by Phase-transfer Catalysis [J].
Chen YH and Long SJ.
Chinese Journal of Pharmaceuticals / Chung-kuo i yao kung yeh tsa chih, 8, 005-005 (2008)
New process for synthesis of 1-acetyl-4-(4-hydroxyphenyl) piperazine [J].
Zheng, CZ, et al.
Huaxue Shiji, 10, 27-27 (2010)
S Shi et al.
Biosensors & bioelectronics, 72, 205-210 (2015-05-20)
We propose in this work a general and versatile methodology for electrochemical monitoring of persistent pharmaceutical micropollutants. The system presented is based on an electroactive and electropolymerized hapten (mimetic molecule of the pollutant to be detected) and a specific antibody

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