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Merck

479306

Sigma-Aldrich

二氯化二胺(II)

≥99.9% trace metals basis

别名:

顺铂, 顺-二氯二氨基铂(II), 顺式-二胺二氯铂, 顺氯氨铂

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About This Item

线性分子式:
Pt(NH3)2Cl2
CAS号:
分子量:
300.05
EC 号:
MDL编号:
UNSPSC代码:
12161600
PubChem化学物质编号:
NACRES:
NA.22
价格与库存信息目前不能提供

质量水平

方案

≥99.9% trace metals basis

反应适用性

core: platinum
reagent type: catalyst

mp

270 °C (lit.)

抗生素抗菌谱

neoplastics

作用机制

DNA synthesis | interferes

SMILES字符串

N.N.Cl[Pt]Cl

InChI

1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2

InChI key

LXZZYRPGZAFOLE-UHFFFAOYSA-L

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应用

二氯化二胺(II)可用作模型药物以测试药物递送中各种药物载体的效率。[1][2][1]
高活性化疗剂,可用于预防睾丸癌的进展。

生化/生理作用

强效的铂基抗肿瘤剂。与 DNA 二核苷酸 d(pGpG) 形成细胞毒性加合物,诱导链内交联。

象形图

Skull and crossbonesHealth hazard

警示用语:

Danger

危险分类

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Questions

1–3 of 3 Questions  
  1. How can I get Product 479306, cis-Diammineplatinum(II) dichloride, in solution?

    1 answer
    1. cis-Diammineplatinum(II) dichloride is soluble in water at 25°C. It is also soluble in N,N-dimethylformamide (DMF), dimethylacetamide and dimethyl sulfoxide (DMSO). We do not test solution stability of this product. However, we do have stability data on a document on another cis-Diammineplatinum(II) dichloride product; the product number is P4394.

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  2. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  3. How should Product 479306, cis-Diammineplatinum(II) dichloride be stored?

    1 answer
    1. This product should be stored at room temperature.

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