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F6020

Sigma-Aldrich

Fenofibrate

≥99% (TLC), powder, PPARα agonist

Synonym(s):

2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid isopropyl ester

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About This Item

Empirical Formula (Hill Notation):
C20H21ClO4
CAS Number:
49562-28-9
Molecular Weight:
360.83
EC Number:
256-376-3
MDL number:
MFCD00133314
UNSPSC Code:
12352200
PubChem Substance ID:
24278015
NACRES:
NA.77
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Product Name

Fenofibrate, ≥99%, powder

Assay

≥99%

form

powder

color

off-white

originator

Abbott

storage temp.

room temp

SMILES string

CC(C)OC(=O)C(C)(C)Oc1ccc(cc1)C(=O)c2ccc(Cl)cc2

InChI

1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3

InChI key

YMTINGFKWWXKFG-UHFFFAOYSA-N

Gene Information

human ... PPARA(5465)

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Application

Fenofibrate has been used:
  • to study its effect on plasma lipids, liver phenotype and gene expression[1]
  • to study its impact on endothelium-dependent vasodilatation of thoracic aorta[2]
  • to administer to NASH knock-in mice along with a high fat diet (HFD) to study its effect[3]

Biochem/physiol Actions

Fenofibrate increases high density lipoprotein levels by reducing cholesteryl ester transfer protein expression. It is used in treating the condition of increased cholesterol levels in the blood, abnormal lipid levels in the body and also hypertriglyceridaemia. Fenofibrate is a lipid regulating drug and proliferator-activated receptor-α (PPARα) mediates its action. It decreases the plasma levels of fibrinogen and C-reactive protein. By this fenofibrate allows better flow-mediated dilatation and reduces the risk of atherosclerosis. Fenofibrate is also known to reduce uric acid levels.[4]

Features and Benefits

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H373

Precautionary Statements

P260 - P314 - P501

Hazard Classifications

STOT RE 2 Oral

Target Organs

Liver

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH7094
BCCB4083
BCBQ5856V
BCBQ5856
BCBL6261V

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Oshri Avraham et al.
eLife, 10 (2021-09-30)
Sensory neurons with cell bodies in dorsal root ganglia (DRG) represent a useful model to study axon regeneration. Whereas regeneration and functional recovery occurs after peripheral nerve injury, spinal cord injury or dorsal root injury is not followed by regenerative
Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice
Wouters K, et al.
Febs Letters, 584(5), 1001-1005 (2010)
Fenofibrate
Keating GM and Croom KF
Drugs, 67(1), 121?153-121?153 (2012)
Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates
Shiri-Sverdlov R, et al.
Journal of Hepatology, 44(4), 732-741 (2006)
Sujeong Park et al.
Experimental & molecular medicine, 53(7), 1159-1169 (2021-07-22)
In this study, we hypothesized that deregulation in the maintenance of the pool of coenzyme A (CoA) may play a crucial role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Specific deletion of Acot12 (Acot12-/-), the major acyl-CoA thioesterase
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Questions

1–3 of 3 Questions  

  1. How should F6020 be stored for long term after resuspending in DMSO?

    1 answer

    1. Unfortunately, the solution stability of this product is not determined.

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  2. Can F6020, Fenofibrate be used for cell culture assays?

    1 answer

    1. This product is not tested for tissue culture applications. Refer to the Certificate of Analysis for release specifications.

      Helpful?

  3. Could you provide the solubility information for item F6020, Fenofibrate?

    1 answer

    1. Fenofibrate is soluble in acetone, ether, DMSO (15 mg/ml), DMF (30 mg/ml), ethanol (1 mg/ml), methanol (slightly soluble), benzene, chloroform, DMF:PBS (1:3 pH 7.2) (0.25 mg/ml), ethyl acetate, acetonitrile, and hexane. However, it is insoluble in water.

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