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Actinonin

Name: Actinonin
Brand: SIGMA

≥98% (TLC), powder, leucine aminopeptidase inhibitor

Synonym(s):

3-[[1-[(2-(Hydroxymethyl)-1-pyrrolidinyl)carbonyl]-2-methylpropyl]carbamoyl]octanohydroxamic acid

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₃₅N₃O₅

CAS Number:

13434-13-4

Molecular Weight:

385.50

NACRES:

NA.77

PubChem Substance ID:

24278232

UNSPSC Code:

12352200

MDL number:

MFCD00080257

Beilstein/REAXYS Number:

1555250

Assay:

≥98% (TLC)

Form:

powder

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Properties

Product Name

Actinonin,

biological source

synthetic (organic)

Quality Segment

200

assay

≥98% (TLC)

form

powder

solubility

ethanol: 50 mg/mL, clear, colorless

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

CCCCCC(CC(=O)NO)C(=O)NC(C(C)C)C(=O)N1CCCC1CO

InChI

1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)

InChI key

XJLATMLVMSFZBN-UHFFFAOYSA-N

Gene Information

human ... ANPEP(290), DPP4(1803), ECE1(1889), LAP3(51056)

Description

General description

Chemical structure: peptide

Application

Actinonin has been used as a control to inhibit meprin-β activity in C57BL/6 mice. It has also been used to study the high-affinity interaction of EcPDF with actinonin by 15N NMR spectroscopy and isothermal titration.

Biochem/physiol Actions

Actinonin is an inhibitor of leucine aminopeptidase. Actinonin has also been used to improve antibacterial activity and antiobesity therapeutics.

Actinonin has inhibitory action against peptide deformylase (PDF). It is effective against Gram-positive and fastidious Gram-negative microorganisms.

Features and Benefits

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item	94261	A3862	EHU082101
Sigma-Aldrich A6671 Actinonin	Sigma-Aldrich 94261 LL-37 (human) trifluoroacetate salt	Sigma-Aldrich A3862 Cefpirome sulfate	Sigma-Aldrich EHU082101 MISSION^® esiRNA
description -	description ≥95% (HPLC)	description -	description targeting human ECE1
assay ≥98% (TLC)	assay ≥95% (HPLC)	assay -	assay -
form powder	form powder (Lyophilisate)	form powder	form lyophilized powder
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C
solubility ethanol: 50 mg/mL, clear, colorless	solubility H₂O: 1 mg/mL, clear, colorless	solubility -	solubility -
antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria	antibiotic activity spectrum Gram-positive bacteria, Gram-negative bacteria, viruses	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria	antibiotic activity spectrum -

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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