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Cefuroxime

VETRANAL®, analytical standard

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About This Item

Empirical Formula (Hill Notation):
C16H16N4O8S
CAS Number:
Molecular Weight:
424.39
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

storage temp.

2-8°C

SMILES string

[H][C@]12SCC(COC(N)=O)=C(N1C(=O)[C@H]2NC(=O)\C(=N/OC)c3ccco3)C(O)=O

InChI

1S/C16H16N4O8S/c1-26-19-9(8-3-2-4-27-8)12(21)18-10-13(22)20-11(15(23)24)7(5-28-16(17)25)6-29-14(10)20/h2-4,10,14H,5-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24)/b19-9-/t10-,14-/m1/s1

InChI key

JFPVXVDWJQMJEE-IZRZKJBUSA-N

General description

Cefuroxime is a new broad-spectrum cephalosporin antibiotic, with increased stability to β-lactamases. It is actively used against gram-positive organisms, including penicillinase-producing staphylococci and non-β-lactamase-producing gram-negative bacteria.
Chemical structure: ß-lactam

Application

Cefuroxime may be used as a reference standard in the determination of cefuroxime in plasma samples using high-performance liquid chromatography (HPLC).(3)
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Ronit Confino-Cohen et al.
The journal of allergy and clinical immunology. In practice, 5(3), 669-675 (2017-05-10)
Penicillins are the drug family most commonly associated with hypersensitivity reactions. Current guidelines recommend negative skin tests (ST) before re-administering penicillins to patients with previous nonimmediate reactions (NIR). The objective of this study was to examine whether ST are necessary
Cefuroxime: human pharmacokinetics.
Foord DR.
Antimicrobial Agents and Chemotherapy, 9(5), 741-747 (1976)
Till Junker et al.
Swiss medical weekly, 142, w13616-w13616 (2012-09-06)
Surgical site infections (SSI) are the most common hospital-acquired infections among surgical patients, with significant impact on patient morbidity and health care costs. The Basel SSI Cohort Study was performed to evaluate risk factors and validate current preventive measures for
Sathish Srinivasan et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 35(8), 538-542 (2019-08-09)
To evaluate the posterior segment visualization in patients with small-aperture intraocular lens (IOL) implantation. In this prospective, comparative case series, 15 patients who had unilateral implantation of the small-aperture IOL in their non-dominant eyes were recruited. Their fellow eyes were

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