G1251

L-Glutamic acid

≥99% (HPLC), suitable for microbiological culture, ReagentPlus^®

• Synonyme(s) : (S)-2-Aminopentanedioic acid, Glu
• Formule linéaire : HO₂CCH₂CH₂CH(NH₂)CO₂H
• Numéro CAS: 56-86-0
• Poids moléculaire : 147.13
• Beilstein: 1723801
• Numéro CE : 200-293-7
• Numéro MDL: MFCD00002634
• Code UNSPSC : 12352209
• eCl@ss : 32160406
• ID de substance PubChem : 24895052
• Nomenclature NACRES : NA.26

Propriétés

• Nom du produit: L-Glutamic acid, ReagentPlus^®, ≥99% (HPLC)
• Agence: suitable for SM 5210
• Niveau de qualité: 200
• Gamme de produits: ReagentPlus^®
• Essai: ≥99% (HPLC)
• Forme: powder
• Technique(s): microbiological culture: suitable
• Couleur: white to off-white
• Pf: 205 °C (dec.) (lit.)
• Solubilité: 1 M HCl: soluble 100 mg/mL
• Densité: 1.54 g/cm³ at 20 °C
• Traces de cations: C: 40.4-41.2%; N: 9.2-9.8%
• Chaîne SMILES: N[C@@H](CCC(O)=O)C(O)=O
• InChI: 1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
• Clé InChI: WHUUTDBJXJRKMK-VKHMYHEASA-N
• Informations sur le gène: human ... CCR2(1231) , GRIA1(2890) , GRIA2(2891) , GRIA4(2893) , GRIK2(2898) , GRIK3(2899) , GRIK5(2901) , GRIN2B(2904) , GRM2(2912) , SLC1A1(6505) , SLC1A2(6506) ; rat ... Gria1(50592) , Grik1(29559) , Grik2(54257) , Grik4(24406) , Grin2a(24409) , Grm1(24414) , Grm2(24415) , Grm3(24416) , Grm4(24417) , Grm5(24418) , Grm6(24419) , Grm7(81672) , Slc1a2(29482)

Description

Application

L-Glutamic acid has been used to enhance endogenous acetylcholine overflow. It has been used as a supplement in the growth medium of meat-Spoiling Pseudomonas fragi 72.

Actions biochimiques/physiologiques

An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).

Glutamic acid, or glutamate, the salt form of glutamic acid, functions as a neurotransmitter and also serves as a precursor to other neurotransmitters such as γ-aminobutyric acid. Glutamic acid also plays a key role in many metabolic pathways, that controls growth, reproduction, maintenance and immunity. It is converted to α-ketoglutarate, a key component of the TCA (tricarboxylic acid) cycle, and a precursor for the biosynthesis of nucleic acids and certain amino acids. In cells, glutamine is converted to glutamate by the enzyme glutaminase.
Glutamine serves as a source of energy for rapidly dividing cells comprising lymphocytes, enterocytes, macrophages and tumors. Glutamine mediates protein turnover via cellular mTOR (mammalian target of rapamycin) signaling. It is also known to be associated with the inhibition of apoptosis.

Informations légales

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)