A-916
7-Aminoclonazepam solution
1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®
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About This Item
Empirical Formula (Hill Notation):
C15H12ClN3O
CAS Number:
Molecular Weight:
285.73
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
Recommended Products
grade
certified reference material
Quality Level
form
liquid
feature
SNAP-N-SPIKE®, SNAP-N-SHOOT®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
1.0 mg/mL in acetonitrile
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
clinical testing
format
single component solution
storage temp.
2-8°C
SMILES string
NC1=CC=C2C(C(C3=C(Cl)C=CC=C3)=NCC(N2)=O)=C1
InChI
1S/C15H12ClN3O/c16-12-4-2-1-3-10(12)15-11-7-9(17)5-6-13(11)19-14(20)8-18-15/h1-7H,8,17H2,(H,19,20)
InChI key
HEFRPWRJTGLSSV-UHFFFAOYSA-N
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General description
This certified Snap-N-Spike® solution is suitable for use as a starting material in calibrators and controls for numerous GC/MS or LC/MS applications in forensic analysis, clinical toxicology and urine drug testing. As a major metabolite, 7-aminoclonazepam may be used to monitor use of the parent drug, clonazepam. Clonazepam, marketed as Klonopin® and Rivotril, is a long-acting benzodiazepine with anxiolytic, anticonvulsant, muscle relaxant, and hypnotic properties.
Application
- 7-Aminoclonazepam as a Reference Standard in Forensic Toxicology: This benzodiazepine metabolite is critical for forensic applications, where it serves as a reference standard for the confirmation and quantitation of clonazepam in biological samples. Its reliable detection in toxicological screenings is crucial for legal and medical interpretations (Elenstål et al., 2023).
- Pharmacokinetic Studies with 7-Aminoclonazepam: In pharmacokinetics, 7-Aminoclonazepam is studied to understand the metabolic pathways of clonazepam, particularly its transformation and elimination in the human body. This research is vital for developing dosing regimens that optimize therapeutic outcomes while minimizing side effects (Øiestad et al., 2023).
- Stability Studies of 7-Aminoclonazepam: Stability testing of 7-Aminoclonazepam in various storage conditions provides essential data on how storage conditions affect the integrity of this compound. Such information ensures the accuracy and reliability of bioanalytical assays used in clinical and forensic settings (Dahlin & Petrides, 2022).
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Klonopin is a registered trademark of Hoffmann-La Roche Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
related product
Product No.
Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
Flash Point(F)
35.6 °F - closed cup
Flash Point(C)
2 °C - closed cup
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Marjorie Chèze et al.
Forensic science international, 145(2-3), 123-130 (2004-09-29)
The number of reports on drug facilitated crimes is increasing these last years. Apart from ethanol and cannabis, benzodiazepines (BZD) and analogs are the most common drugs reported to be used probably due to their amnesic and sedative properties. We
D R Peng et al.
Pediatric pharmacology (New York, N.Y.), 4(3), 155-159 (1984-01-01)
The N-acetylation of the reduced metabolite of clonazepam 7-amino-clonazepam was studied in cytosolic preparation from human fetal and adult livers. The metabolite formed 7-acetamido-clonazepam was measured with high performance liquid chromatography. A bimodal distribution of the N-acetyltransferase activities was observed
Wei Chen et al.
Biosensors & bioelectronics, 24(7), 2051-2056 (2008-12-09)
The present paper described a rapid and ultrasensitive detection method using a microfluidic chip for analyzing 7-aminoclonazepam (7-ACZP) residues in human urine. A microfluidic chip-based immunoassay with laser-induced fluorescence (LIF) detection based on the water-soluble denatured bovine serum albumin (dBSA)-coated
A Negrusz et al.
Journal of analytical toxicology, 24(7), 614-620 (2000-10-24)
Clonazepam (CLO) is an anticonvulsant benzodiazepine approved by the Food and Drug Administration for use in the treatment of seizures. It produces pharmacological effects (depression, amnesia) similar to other compounds from the same therapeutic class, and in combination with alcohol
Simple high-performance liquid chromatographic assay for the routine monitoring of clonazepam in plasma.
R L Heazlewood et al.
Journal of chromatography, 336(1), 229-233 (1984-12-07)
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