SML3588

J147

≥98% (HPLC)

• Synonyme(s) : (E)-N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N′-(3-methoxybenzylidene)acetohydrazide, 2,2,2-Trifluoro-acetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide, J 147
• Formule empirique (notation de Hill): C₁₈H₁₇F₃N₂O₂
• Numéro CAS: 1807913-16-1
• Poids moléculaire : 350.33
• Numéro MDL: MFCD25976644
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 2 mg/mL, clear (Warmed)
• Température de stockage: 2-8°C
• Chaîne SMILES: COC1=CC(/C=N/N(C2=C(C=C(C=C2)C)C)C(C(F)(F)F)=O)=CC=C1

Description

Actions biochimiques/physiologiques

J147 is a broadly neuroprotective (in multiple assays) compound that enhances the memory in normal and Alzheimer’s disease (AD) transgenic mice. J147 has neurotrophic and BDNF-like activities that are independent of the BDNF receptor, and TrkB. Also it appears that J147 has a small but significant effect on Ab metabolism by reducing Ab1–42 in the soluble fraction of the hippocampus.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable