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Key Documents

SML0594

Sigma-Aldrich

CGP 55845 hydrochloride

≥98% (HPLC)

Synonyme(s) :

(2S)-3-[[(1S)-1-(3,4-Dichlorophenyl)ethyl]amino-2-hydro xypropyl](phenylmethyl)phosphinic acid hydrochloride, CGP 55845A, CGP55845

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About This Item

Formule empirique (notation de Hill):
C18H22Cl2NO3P · HCl
Numéro CAS:
149184-22-5
Poids moléculaire :
438.71
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Conditions de stockage

desiccated

Couleur

white to beige

Solubilité

DMSO: 5 mg/mL, clear (warmed)

Température de stockage

room temp

InChI

1S/C18H22Cl2NO3P/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23,24)11-14-5-3-2-4-6-14/h2-9,13,16,21-22H,10-12H2,1H3,(H,23,24)/t13-,16-/m0/s1

Clé InChI

ZODSPDOOCZZEIM-BBRMVZONSA-N

Actions biochimiques/physiologiques

CGP 55845 is a potent selective GABA-B receptor antagonist with an IC50 of 5 nM.

Caractéristiques et avantages

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAB Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Ahmad A Khundakar et al.
European journal of pharmacology, 671(1-3), 33-38 (2011-09-21)
Brain-derived neurotrophic factor (BDNF) has been suggested as a target for antidepressant treatment and chronic antidepressant drug administration shows a 'biphasic effect' on BDNF mRNA in rat hippocampus (transient decrease followed by an increase). In comparison, following acute administration only
Wendy W Wu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(7), 2638-2648 (2011-02-18)
Premature and uncompensated loss of ovarian hormones following ovariectomy (OVX) elevates the risks of cognitive impairment and dementia. These risks are prevented with estrogen (E(2))-containing hormone replacement therapy initiated shortly following OVX but not after substantial delay. Currently, the cellular
Mark O Cunningham et al.
Epilepsia, 53(7), 1205-1214 (2012-06-13)
We describe a form of very fast oscillation (VFO) in patient electrocorticography (ECoG) recordings, that can occur prior to ictal events, in which the frequency increases steadily from ≈ 30-40 to >120 Hz, over a period of seconds. We dub
Niccolò P Pampaloni et al.
Cell reports, 36(5), 109496-109496 (2021-08-05)
Glutamate receptor ion channels, including α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, mediate fast excitatory neurotransmission in the CNS. Previous work suggested that AMPA receptors produce a synaptic current with a millisecond duration. However, we find that about two-thirds of principal cells in
Carolina Cabezas et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(34), 11835-11840 (2012-08-24)
Dentate gyrus granule cells have been suggested to corelease GABA and glutamate both in juvenile animals and under pathological conditions in adults. Although mossy fiber terminals (MFTs) are known to express glutamic acid decarboxylase (GAD) in early postnatal development, the
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