S7817

Scriptaid

≥95%, solid

• Synonyme(s) : 6-(1,3-Dioxo-1H, 3H-benzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide
• Formule empirique (notation de Hill): C₁₈H₁₈N₂O₄
• Numéro CAS: 287383-59-9
• Poids moléculaire : 326.35
• Numéro MDL: MFCD00386477
• Code UNSPSC : 12352203
• ID de substance PubChem : 329824590
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 100
• Pureté: ≥95%
• Forme: solid
• Pf: 160-161 °C
• Solubilité: DMSO:methanol (1:1): complete 2 mg/ml, clear, colorless to faintly yellow; DMSO: 1 mg/mL; methanol: soluble
• Température de stockage: −20°C
• Chaîne SMILES: ONC(=O)CCCCCN1C(=O)c2cccc3cccc(C1=O)c23
• InChI: 1S/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21)
• Clé InChI: JTDYUFSDZATMKU-UHFFFAOYSA-N

Description

Description générale

Scriptaid is a histone deacetylase (HDAC) inhibitor, which enhances global acetylation of histones. It improves transcriptional activity and protein expression. Scriptaid inhibits tumor growth. It decreases telomerase activity and stimulates glioma cell apoptosis.

Application

Scriptaid has been used in post activation of oocytes and embryo culture.

Scriptaid was used to enhance transcriptional activity in cloning procedures by somatic cell nuclear transfer.^5,6

Actions biochimiques/physiologiques

Histone deacetylase inhibitor with lower toxicity than trichostatin A; used to enhance protein expression.

Scriptaid inhibits the cell cycle progression of ovarian cancer cells by inducing arrest in G0/G1 and/or G2/M phase. Treatment of cells with scriptaid results in loss of mitochondrial membrane potential and increased acetylation of H3 and H4 histone tails.² Sciptaid induces expression of γ-globin in human erythroid progenitors via p38 signaling and may be a treatment option for sickle cell disease.³ It enhances the transcriptional activity and protein expression in mouse embryos. This is useful in producing cloned, inbred mouse embryos that develop normally into adulthood with regular reproductive ability.⁴

Caractéristiques et avantages

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Informations légales

Sold under license of U.S. Patent No. 6,544,957.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)