R109

Ro 15-4513

solid

• Synonyme(s) : Ethyl 8-azido-6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate, Ro15-4513
• Formule empirique (notation de Hill): C₁₅H₁₄N₆O₃
• Numéro CAS: 91917-65-6
• Poids moléculaire : 326.31
• Numéro MDL: MFCD00078598
• Code UNSPSC : 12352200
• ID de substance PubChem : 24899343
• Nomenclature NACRES : NA.77

Propriétés

• Forme: solid
• Niveau de qualité: 100
• Couleur: tan
• Solubilité: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.8 mg/mL; H₂O: insoluble; methanol: soluble
• Auteur: Roche
• Chaîne SMILES: CCOC(=O)c1ncn-2c1CN(C)C(=O)c3cc(ccc-23)N=[N+]=[N-]
• InChI: 1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3
• Clé InChI: CFSOJZTUTOQNIA-UHFFFAOYSA-N
• Informations sur le gène: human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA5(2558) , GABRA6(2559) ; rat ... Gabrg1(140674)

Description

Application

Ro 15-4513 has been used as a benzodiazepine (Bz) inverse agonist in rats and to test its binding with diazepam-sensitive (DS) receptors in in vitro radioligand binding studies.

Actions biochimiques/physiologiques

Ro 15-4513 is benzodiazepine receptor partial inverse agonist. It elicits anxiogenic property and is an ethanol antagonist. It elicits a high affinity towards diazepam sensitive and insensitive sites in the cerebellar region. Ro 15-4513 possesses an imidazo ring and is an imidazobenzodiazepine.

Caractéristiques et avantages

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)