P5515

Prostaglandin E₁

≥98% (HPLC), powder, vasodilator 

• Synonyme(s) : (11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid, Alprostadil, PGE₁
• Formule empirique (notation de Hill): C₂₀H₃₄O₅
• Numéro CAS: 745-65-3
• Poids moléculaire : 354.48
• Numéro Beilstein : 5294062
• Numéro CE : 212-017-2
• Numéro MDL: MFCD00077860
• Code UNSPSC : 12352211
• eCl@ss : 42020658
• ID de substance PubChem : 57654538
• Nomenclature NACRES : NA.77

Propriétés

• product name: Prostaglandin E₁, ≥98% (HPLC), synthetic
• Source biologique: synthetic
• Niveau de qualité: 200
• Pureté: ≥98% (HPLC)
• Forme: (powder to crystals)
• Solubilité: ethanol: 5 mg/mL
• Température de stockage: −20°C
• Chaîne SMILES: O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1
• InChI: 1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
• Clé InChI: GMVPRGQOIOIIMI-DWKJAMRDSA-N
• Informations sur le gène: human ... PTGER1(5731) , PTGER2(5732) , PTGIR(5739) ; mouse ... Ptger1(19216) , Ptger2(19217) , Ptger3(19218) , Ptger4(19219)

Description

Application

Prostaglandin E1 has been used:

• as a platelet inhibitor to analyse its effect on autophagy
• in platelet adhesion assay
• to investigate its effect on cAMP production in thyroid glands of normal and growth-retarded mouse in vitro.

Actions biochimiques/physiologiques

Prostaglandin E1 (PGE1) is a hormone synthesized from dihomo-γ-linolenic acid (DGLA) by the action of enzyme prostaglandin synthase. It is a vasodilator and activates adenylate cyclase. It is majorly present in human semen and is a potent platelet aggregation inhibitor. PGE1 infusions is effective in treating limb ischemia and peripheral vascular disease. It is unstable and is hydrolyzed to PGA1 in the lungs. Nanoparticle encapsulation of PGE1 is essential for its delivery at the vascular injury site. It elicits vasodilator effects on the retinal artery and vein in central retinal artery occlusion (CRAO). PGE1 and its synthetic analog misoprostol interact with E-prostanoid receptor 4 (EP4) and elicits protection in chronic myelogenous leukemia (CML).

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P301 + P310 + P330
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves