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P2517

Sigma-Aldrich

L-α-Phosphatidylinositol ammonium salt solution from bovine liver

10 mg/mL in chloroform, ≥98% (TLC)

Synonyme(s) :

1,2-Diacyl-sn-glycero-3-phospho-(1-D-myo-inositol), PI, PtdIns

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About This Item

Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

Niveau de qualité

200

Pureté

≥98% (TLC)

Concentration

10 mg/mL in chloroform

Température de stockage

−20°C

Actions biochimiques/physiologiques

Phosphatidylinositol is a phosphoglyceride, containing inositol as a cyclohexanol head group. The phosphatidylinositol signaling pathway is also called as double signaling pathway as it generates two secondary messengers. It is associated with a number of physiological processes in plants. This includes the development of pollen and vascular organs, root and root hair growth, hormone response and stress tolerance.
Phospholipid membrane component, precursor of inositol phosphates.

Caractéristiques et avantages

This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Autres remarques

Contains primarily stearic and arachidonic acids.

Pictogrammes

Skull and crossbonesHealth hazard
GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Organes cibles

Central nervous system, Liver,Kidney

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

S J Heydrick et al.
The Journal of clinical investigation, 91(4), 1358-1366 (1993-04-01)
Activation of phosphatidylinositol-3-kinase (PI3K) is one of the earliest postreceptor events in the insulin signaling pathway. Incubation of soleus muscles from lean mice with 50 nM insulin caused a 3-10-fold increase in antiphosphotyrosine-immunoprecipitable PI3K (antiPTyr-PI3K) activity within 2 min in
Cell Biology, 471-471 (2007)
Functional Characterization of Arabidopsis Phosphatidylinositol Monophosphate 5-kinase 2 in Lateral Root Development, Gravitropism and Salt Tolerance, 2-2 (2014)
Sarah J Tilley et al.
Structure (London, England : 1993), 12(2), 317-326 (2004-02-14)
Phosphatidylinositol transfer protein alpha (PITPalpha) selectively transports and promotes exchange of phosphatidylinositol (PI) and phosphatidylcholine (PC) between lipid bilayers. In higher eukaryotes PITPalpha is required for cellular functions such as phospholipase C-mediated signaling, regulated exocytosis, and secretory vesicle formation. We
L Raptis et al.
Journal of virology, 63(2), 753-758 (1989-02-01)
Polyomavirus middle tumor antigen (mT) was expressed in a line of mouse NIH 3T3 cells under control of the dexamethasone-regulatable mouse mammary tumor virus promotor. Contrary to rat F111 cells which were rendered anchorage independent by mT expression alone (L.
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