C0563
Cardiolipin sodium salt from bovine heart
≥97% (TLC), lyophilized powder
Synonyme(s) :
Diphosphatidylglycerol
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About This Item
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![14:0 Cardiolipin (sodium salt) 1′,3′-bis[1,2-dimyristoyl-sn-glycero-3-phospho]-glycerol (sodium salt), powder](/deepweb/assets/sigmaaldrich/product/images/390/523/992bed4e-3608-4209-aa6e-fa9206a4a31b/640/992bed4e-3608-4209-aa6e-fa9206a4a31b.jpg)
Source biologique
bovine heart
Niveau de qualité
Pureté
≥97% (TLC)
Forme
lyophilized powder
Type de lipide
phosphoglycerides
Conditions d'expédition
ambient
Température de stockage
−20°C
Description générale
Cardiolipin is localized in the inner membrane of mitochondria. It contains 18 carbon atoms, 3-phosphatidyl groups connected via a glycerol bridge. Cardiolipin is an important component of ATP synthase enzyme.
Application
Cardiolipin sodium salt from bovine heart has been used:
- as a phospholipid standard in thin layer chromatography for the quantification of total mitochondrial lipids of Neurospora crassa(89)
- as an internal standard in reverse phase high performance liquid chromatography (RP-HPLC) for quantification of bacterial lipid extracts(90)
- as an antigen to evaluate IgM reaction in systemic lupus erythematosus (SLE) patients(91)
Actions biochimiques/physiologiques
Cardiolipin is a mitochondrial phospholipid that is found in mammalian tissues in low concentrations. It is often a membrane component. Inhibits cell attachment of fibronectin, vitronectin and Type I collagen.
Conditionnement
packaged under argon
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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Les clients ont également consulté
Ze-Wei Ma et al.
Acta pharmacologica Sinica, 39(6), 1012-1021 (2017-12-22)
Humanin (HN) is a 24-residue peptide identified from the brain of a patient with Alzheimer's disease (AD). HN has been found to protect against neuronal insult caused by Aβ peptides or transfection of familial AD mutant genes. In order to
Analysis of mutations in Neurospora crassa ERMES components reveals specific functions related to beta-barrel protein assembly and maintenance of mitochondrial morphology
Wideman JG, et al.
PLoS ONE, 8(8), e71837-e71837 (2013)
Lu Luo et al.
The Journal of biological chemistry, 289(46), 31708-31718 (2014-10-08)
Bax is a pro-apoptotic Bcl-2 family protein. The activated Bax translocates to mitochondria, where it forms pore and permeabilizes the mitochondrial outer membrane. This process requires the BH3-only activator protein (i.e. tBid) and can be inhibited by anti-apoptotic Bcl-2 family
Lenette L Lu et al.
Nature medicine, 25(6), 977-987 (2019-05-22)
Exposure to Mycobacterium tuberculosis (Mtb) results in heterogeneous clinical outcomes including primary progressive tuberculosis and latent Mtb infection (LTBI). Mtb infection is identified using the tuberculin skin test and interferon-γ (IFN-γ) release assay IGRA, and a positive result may prompt
Cardiolipin binds selectively but transiently to conserved lysine residues in the rotor of metazoan ATP synthases
Duncan AL, et al.
Proceedings of the National Academy of Sciences of the USA, 113(31), 8687-8692 (2016)
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