P0667

Parthenolide

≥98% (HPLC)

• Formule empirique (notation de Hill): C₁₅H₂₀O₃
• Numéro CAS: 20554-84-1
• Poids moléculaire : 248.32
• Numéro MDL: MFCD00134592
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278621
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Pf: 115-116 °C (lit.)
• Température de stockage: 2-8°C
• Chaîne SMILES: C/C(CC[C@]12[H])=C/CC[C@]3(C)[C@H](O3)[C@]1(OC(C2=C)=O)[H]
• InChI: 1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5-/t11-,12-,13+,15+/m0/s1
• Clé InChI: KTEXNACQROZXEV-ZRPLFPEYSA-N
• Informations sur le gène: human ... ELA2(1991) , IKBKG(8517) , NFKB1(4790) , NKAP(79576) , NKRF(55922)

Description

Application

Parthenolide has been used:

• in the crystallization with vasohibin 1 (VASH1) to study tubulin detyrosination inhibition
• as an inhibitor of nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) and signal transduction and activation of transcription (STAT) inhibitor to study its effects on the cytoadhesion of CD36-binding Plasmodium falciparum-infected erythrocytes (IECD36)
• as a lipophilic agent to study its effects on the production of interleukin?13 and interferon?γ by peripheral blood-derived CD8⁺ T cells

Actions biochimiques/physiologiques

Parthenolide is a sesquiterpene lactone present abundantly in the leaves and flowers of Tanacetum parthenium. It exhibits anti-cancer properties for the treatment of invasive cancers. Parthenolide exhibits therapeutic effects against inflammation and migraine. It plays a role in signal transduction and activation of transcription (STAT)-inhibition-mediated transcriptional repression of pro-apoptotic genes.

Anti-inflammatory agent that inhibits NF-κB activation.

Autres remarques

Sesquiterpene lactone found in feverfew (Tanacetum parthenium) and other plants.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H317
• Conseils de prudence: P280 - P302 + P352
• Classification des risques: Skin Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)