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M4008

Sigma-Aldrich

Morin hydrate

powder

Synonyme(s) :

2′,3,4′,5,7-Pentahydroxyflavone

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About This Item

Formule empirique (notation de Hill):
C15H10O7 · xH2O
Numéro CAS:
654055-01-3
Poids moléculaire :
302.24 (anhydrous basis)
Numéro CE :
207-542-9
Numéro MDL:
MFCD00217054
Code UNSPSC :
12171500
ID de substance PubChem :
24278552
Nomenclature NACRES :
NA.77

Forme

powder

Niveau de qualité

100

Couleur

yellow

Solubilité

methanol: 50 mg/mL

Chaîne SMILES 

O.Oc1ccc(c(O)c1)C2=C(O)C(=O)c3c(O)cc(O)cc3O2

InChI

1S/C15H10O7.H2O/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15;/h1-5,16-19,21H;1H2

Clé InChI

MYUBTSPIIFYCIU-UHFFFAOYSA-N

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Application

Morin hydrate has been used:
  • to investigate its antitumor functionality using cell viability and apoptosis assay in human cancer cell lines.
  • as a fluorescence stain to detect aluminum in motor neurons and lumbar cord.
  • to study its protective effect on neuronal hearing loss and on neural stem cells (NSCs) proliferation and differentiation

Actions biochimiques/physiologiques

Morin hydrate is a flavonoid with antioxidant properties. It has been shown to protect cells against oxygen radical damage. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase, a free-radical generating enzyme. At concentrations of 75-100 micromolar, morin inhibits oxidation of low density lipoprotein (LDL) by free radicals or Cu2+. Morin has been reported to inhibit rat brain phospha­tidyl­inositol­phos­phate kinase activity in vitro and in vivo.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
MKCW3839
MKCV7298
MKCW0670
MKCV7299
0000270749

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T W Wu et al.
Biochemical pharmacology, 49(4), 537-543 (1995-02-14)
Morin hydrate is a bioactive pigment found in yellow Brazil wood. Recently, we reported that morin hydrate prolongs the survival of three types of cells from the human circulatory system against oxyradicals generated in vitro. The protection excels that given
T W Wu et al.
Life sciences, 58(2), PL 17-PL 22 (1996-01-01)
We demonstrated that the flavonoid morin hydrate at 75-100 microM protects against the oxidation of low density lipoprotein (LDL) by free radicals produced by 2,2'-azo-bis(2-amidinopropane) dihydrochloride. Morin hydrate reduces the relative electrophoretic mobility, malondialdehyde equivalents and lipid peroxide level of
Christopher A Shaw et al.
Journal of inorganic biochemistry, 103(11), 1555-1562 (2009-09-11)
Gulf War Syndrome is a multi-system disorder afflicting many veterans of Western armies in the 1990-1991 Gulf War. A number of those afflicted may show neurological deficits including various cognitive dysfunctions and motor neuron disease, the latter expression virtually indistinguishable
T W Wu et al.
Life sciences, 57(3), PL51-PL56 (1995-01-01)
Oxidative modification of low density lipoprotein (LDL) has been suggested to be a risk factor for the development of atherosclerosis. Agents which can protect LDL from oxidation may be useful in preventing atherogenesis. Here, we found that morin hydrate, at
Shan Yu et al.
Inflammation, 43(4), 1293-1303 (2020-03-07)
Mastitis is one of the most common diseases that both affects human and animals. Morin is derived from the member of Moraceae family, which has been used in the treatment of many inflammatory diseases. The purpose of this study was
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