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H6501

Sigma-Aldrich

DL-β-Hydroxybutyric acid sodium salt

~98%, powder

Synonyme(s) :

(±)-3-Hydroxybutanoic acid sodium salt

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About This Item

Formule linéaire :
C4H7O3Na
Numéro CAS:
150-83-4
Poids moléculaire :
126.09
Numéro CE :
205-774-5
Numéro MDL:
MFCD00016716
Code UNSPSC :
12352204
ID de substance PubChem :
24895744
Nomenclature NACRES :
NA.83

product name

DL-β-Hydroxybutyric acid sodium salt, ~98%

Pureté

~98%

Niveau de qualité

200

Forme

powder

Solubilité

water: 1 g/10 mL, clear, colorless

Température de stockage

2-8°C

Chaîne SMILES 

[Na].CC(O)CC(O)=O

InChI

1S/C4H8O3.Na/c1-3(5)2-4(6)7;/h3,5H,2H2,1H3,(H,6,7);/q;+1/p-1

Clé InChI

NBPUSGBJDWCHKC-UHFFFAOYSA-M

Application

DL-β-Hydroxybutyric acid sodium salt has been used:
  • as a standard for quantifying blood plasma and milk β-hydroxybutyric acid in Danish Jersey cows
  • to investigate its anticonvulsant effects in epilepsy induced rats
  • to induce hyperketonemia in Holstein dairy cows

Actions biochimiques/physiologiques

β-Hydroxybutyric acid is a ketone body present in the rumen epithelium of liver cells. Its interconversion to acetoacetate influences the acid-base balance and is coupled NADH generation from (nicotinamide adenine dinucleotide) NAD+, measured fluorimetrically. A high plasma level of β-hydroxybutyric acid is implicated in diabetic ketoacidosis. It traverses the blood-brain barrier as a monocarboxylic acid. β-Hydroxybutyric acid may play a protective role in dopaminergic neurodegeneration in Parkinson′s disease model. β-Hydroxybutyric acid is a ligand for G protein-coupled receptor(GPR109A) and favors inhibition of secretion, transcription and translation of growth hormone (GH) and prolactin (PRL) gene in cow anterior pituitary cells (DCAPCs).

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Influence of DL-beta-hydroxybutyric acid on cell proliferation and calcium influx
Cheng S, et al.
Biomacromolecules, 6(2), 593-597 (2005)
Jianping Si et al.
Experimental and therapeutic medicine, 14(1), 765-770 (2017-07-05)
The present study aimed to investigate the anticonvulsant effects of β-hydroxybutyrate (BHB) in a kainic acid (KA)-induced rat seizure model. The concentrations of BHB and glucose were detected in the blood prior to exogenous BHB administration. Three different doses of
Gwinyai E Chibisa et al.
Journal of animal science, 98(6) (2020-05-25)
Cattle need physically effective fiber to promote rumination and maintain rumen health, but economics favor the use of low-roughage feedlot diets. The study investigated the optimum barley silage proportion in barley-based finishing diets. Apparent total-tract digestibility (4-d total fecal collection)
Jianping Si et al.
Experimental and therapeutic medicine, 20(6), 177-177 (2020-10-27)
The aim of the present study was to explore the potential anticonvulsant effects of β-hydroxybutyrate (BHB) in a kainic acid (KA)-induced rat epilepsy model. The KA-induced rat seizure model was established and BHB was administrated intraperitoneally at a dose of
Emily R Cope et al.
Physiological genomics, 50(6), 468-477 (2018-04-07)
To identify molecular pathways that couple metabolic imbalances and reproduction, we randomly assigned 10 castrated male sheep to be centrally injected into the lateral ventricle through intracerebroventricular cannulas with 1 ml of β-hydroxybutyric acid sodium salt solution (BHB; 12,800 µmol/l)
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