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H0261

Sigma-Aldrich

DL-β-Hydroxybutyryl coenzyme A lithium salt

≥90%

Synonyme(s) :

DL-3- hydroxybutyryl Coenzyme A lithium salt

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About This Item

Formule empirique (notation de Hill):
C25H42N7O18P3S
Numéro CAS:
103404-51-9
Poids moléculaire :
853.62
Numéro MDL:
MFCD00079336
Code UNSPSC :
41106305
ID de substance PubChem :
24895396
Nomenclature NACRES :
NA.51

Source biologique

synthetic (Organic)

Niveau de qualité

200

Pureté

≥90%

Forme

powder

Solubilité

H2O: soluble-50 mg/mL, clear, colorless

Température de stockage

−20°C

Chaîne SMILES 

[Li].CC(O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1OP(O)(O)=O)n2cnc3c(N)ncnc23

InChI

1S/C25H42N7O18P3S.Li.H/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32;;/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41);;

Clé InChI

HNPHARRBSFXZAL-UHFFFAOYSA-N

Application

DL-β-Hydroxybutyryl coenzyme A lithium salt has been used:

  • as a substrate in the HSD17B4 protein enzymatic assay
  • as a substrate to determine the specificity and kinetics of Hc-DHS-28 and its mutation proteins
  • as a component of the reaction buffer in S-adenosyl-L-homocysteine hydrolase (AHCY) in vitro acylation

Actions biochimiques/physiologiques

3-Hydroxybutyryl coenzyme A (HBCoA) is converted to bacterial polyhydroxyalkanoates (PHB) by polyhydroxybutyrate (PHB) synthases. 3-Hydroxybutyryl coenzyme A is a substrate used to measure the specificity and kinetics of β-hydroxyacyl CoA dehydrogenase.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Kesaven Bhubalan et al.
Applied and environmental microbiology, 77(9), 2926-2933 (2011-03-15)
The synthesis of bacterial polyhydroxyalkanoates (PHA) is very much dependent on the expression and activity of a key enzyme, PHA synthase (PhaC). Many efforts are being pursued to enhance the activity and broaden the substrate specificity of PhaC. Here, we
Ping Li et al.
Biochemistry, 48(39), 9202-9211 (2009-08-29)
Polyhydroxybutyrate (PHB) synthases catalyze the conversion of 3-hydroxybutyryl coenzyme A (HBCoA) to PHB with a molecular mass of 1.5 MDa. The class III synthase from Allochromatium vinosum is a tetramer of PhaEPhaC (each 40 kDa). The polymerization involves covalent catalysis
Enhancement of L-3-hydroxybutyryl-CoA dehydrogenase activity and circulating ketone body levels by pantethine. Relevance to dopaminergic injury.
Cornille E, Abou-Hamdan M, et al.
BMC Neuroscience, 23, 51-51 (2010)
Yi Yang et al.
International journal for parasitology, 50(12), 945-957 (2020-08-29)
Haemonchus contortus could enter the diapause stage to avoid hostile conditions, however the inducing mechanism still remains poorly understood. A similar dauer strategy exists in Caenorhabditis elegans, and dauer phenomones, which are produced through a four step cycle of peroxisomal
An Artemisinin Derivative ART1 Induces Ferroptosis by Targeting the HSD17B4 Protein Essential for Lipid Metabolism and Directly Inducing Lipid Peroxidation
Xie J, et al.
CCS Chemistry, 4(1), 304-317 (2022)
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