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F7807

Sigma-Aldrich

Prostaglandin F Synthase human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonyme(s) :

17-beta-hydroxysteroid dehydrogenase type 5, AKR1C3, aldo-keto reductase family 1 member C3, indanol dehydrogenase

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About This Item

Numéro CAS:
55976-95-9
Numéro de classification (Commission des enzymes):
1.1.1.188 (BRENDA, IUBMB)
Numéro MDL:
MFCD00900598
Code UNSPSC :
12352204
Nomenclature NACRES :
NA.54

Produit recombinant

expressed in E. coli

Niveau de qualité

200

Description

contains a C-terminal hexahistidine tag

Essai

≥90% (SDS-PAGE)

Forme

liquid

Activité spécifique

≥0.4 μmol/mg protein

Poids mol.

~37 kDa

Numéro d'accès NCBI

NP_003730

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... AKR1C3(8644)

Application

Prostaglandin F synthase (PGF synthase) is a member of the aldo-keto reductase superfamily of proteins which catalyze the conversion of aldehydes and ketones to thier corresponding alcohols. Prostaglandin F synthase is used in cancer research since it is upregulated in many cancers such as breast and prostate cancer. PGF synthase is also used to study kidney and renal cell carcinoma .

Actions biochimiques/physiologiques

PGF synthase catalyzes the conversions of 4-androstene-3,17-dione to testosterone, estrone to 17β-estradiol, prostaglandin H2 to PGF2α, and PGD2 to 9α,11β-PGF2. Prostaglandin (PG) F2 is synthesized via three pathways .

Définition de l'unité

One unit is defined as the amount of enzyme required to produce 1 μmol of NADP per minute at 37°C in 50 mM KPO4 pH 7.2 containing 250 μM NADPH and 25 μM 9,10-phenanthrenequinone

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
100M1712

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Dominika Slonina et al.
Prostaglandins & other lipid mediators, 90(3-4), 69-75 (2009-09-15)
The aim was to study whether bovine myometrial cells have an enzymatic system able to produce prostaglandins (PGs) and whether PGs synthesis is regulated by steroids in a similar manner as endometrial cells. In Experiment 1, immunohistochemical studies localized proteins
Mariusz Pawel Kowalewski et al.
Animal reproduction science, 116(1-2), 129-138 (2009-01-24)
In nonpregnant and pregnant dogs the corpora lutea (CL) are the only source of progesterone (P4) which shows an almost identical secretion pattern until the rapid decrease of P4 prior to parturition. For the nonpregnant dog clear evidence has been
R J Phillips et al.
Molecular human reproduction, 17(1), 1-13 (2010-07-03)
Prostaglandins (PGs) are important factors in the physiology of human parturition and the control of uterine contractility. We have characterized the expression of 15 genes from all stages of the PG pathway in human pregnant and non-pregnant (NP) myometrium and
Kikuko Watanabe
Prostaglandins & other lipid mediators, 68-69, 401-407 (2002-11-16)
Prostaglandin (PG) F2 is synthesized via three pathways from PGE2, PGD2, or PGH2 by PGE 9-ketoreductase, PGD 11-ketoreductase, or PGH 9-, 11-endoperoxide reductase, respectively. The enzymological and molecular biological properties of these enzymes have been reported in work over the
Marta Wasielak et al.
Reproduction, fertility, and development, 21(5), 709-717 (2009-06-03)
The present study was conducted to evaluate the effect of the conceptus on uterine prostaglandin-F2alpha (PGF2alpha) and prostaglandin-E2 (PGE2) release and the expression of prostaglandin synthase enzymes during the periimplantation period in the pig. A surgically generated model with conceptuses
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