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Merck
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Principaux documents

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C8753

Sigma-Aldrich

Cholesteryl arachidonate

≥95% (HPLC; detection at 205 nm), viscous liquid

Synonyme(s) :

3β-Hydroxy-5-cholestene 3-arachidonate, 5-Cholesten-3β-ol 3-arachidonate, Cholesteryl eicosatetraenoate

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About This Item

Formule empirique (notation de Hill):
C47H76O2
Numéro CAS:
604-34-2
Poids moléculaire :
673.11
Numéro MDL:
MFCD00056441
Code UNSPSC :
12352211
ID de substance PubChem :
24893099
Nomenclature NACRES :
NA.77

Niveau de qualité

200

Pureté

≥95% (HPLC; detection at 205 nm)

Forme

viscous liquid

Couleur

clear

Groupe fonctionnel

ester

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

CCCCC\C=C\C\C=C\C\C=C\C\C=C\CCCC(=O)OC1CCC2(C)C3CCC4(C)C(CCC4C3CC=C2C1)C(C)CCCC(C)C

InChI

1S/C47H76O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-27-45(48)49-40-32-34-46(5)39(36-40)28-29-41-43-31-30-42(38(4)26-24-25-37(2)3)47(43,6)35-33-44(41)46/h11-12,14-15,17-18,20-21,28,37-38,40-44H,7-10,13,16,19,22-27,29-36H2,1-6H3/b12-11+,15-14+,18-17+,21-20+

Clé InChI

IMXSFYNMSOULQS-SXXSVFILSA-N

Application

Cholesteryl arachidoante was oxidized and used to study the biological effects.

Actions biochimiques/physiologiques

Cholesteryl arachidonate is a cholesterol ester found associated with the neutral core of low density lipoprotein. Receptor-LDL complexes are taken up by lysosomes and hydrolyzed to release cholesterol from the esters. The enzyme acid cholesteryl ester hydrolase is responsible for the hydrolysis of cholesteryl esters; a defective enzyme can result in the formation of atherosclerotic lesions in humans.

Notes préparatoires

Cholesteryl arachidonate is a clear, colorless viscous liquid in chloroform.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Huiyong Yin et al.
The Journal of biological chemistry, 279(5), 3766-3776 (2003-11-05)
Free radical-initiated lipid autoxidation in low density lipoprotein (LDL) has been implicated in the pathogenesis of atherosclerosis. Oxidation of the lipid components of LDL leads to a complex mixture of hydroperoxides, bicyclic endoperoxides, monocyclic peroxides, and serial cyclic peroxides. The
R Y Ball et al.
British journal of experimental pathology, 69(1), 43-56 (1988-02-01)
Murine resident peritoneal macrophages were maintained in cell culture in a medium containing 10% lipoprotein-deficient fetal calf serum to which various artificial lipoprotein particles (coacervates of lipid and bovine serum albumin) had been added. The uptake and intracellular fate of
N Araki et al.
Analytical biochemistry, 185(2), 339-345 (1990-03-01)
A simple and rapid method for the microquantification of cholesterol and cholesteryl esters by reverse-phase high performance liquid chromatography has been established. Comparison of elution patterns of authentic cholesterol and cholesteryl esters revealed that a mu Bondasphere reverse-phase C8 (300-A)
J M Smaby et al.
Biochemistry, 20(4), 724-730 (1981-02-17)
Surface pressure--area isotherms for binary mixtures of cholesteryl octanoate, elaidate, stearate, oleate, linoleate, linolenate, and arachiodonate in mixtures with dioleoyllecithin, triolein, oleic acid, and oleoyl alcohol were measured at 24 degrees C. Analysis of the pressure and area characteristics as
J V Hunt et al.
Atherosclerosis, 98(2), 229-239 (1993-01-25)
Flow cytometry has been examined as a method for quantitative measurement of the accumulation in macrophages of ceroid, an autofluorescent polymer composed of oxidised protein and lipid. Murine peritoneal macrophages were cultured in the presence of cholesteryl linoleate- or arachidonate-bovine
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