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N0560000

Niclosamide

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

Niclosamide, 2′,5-Dichloro-4′-nitrosalicylanilide

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About This Item

Formule empirique (notation de Hill):
C13H8Cl2N2O4
Numéro CAS:
50-65-7
Poids moléculaire :
327.12
Numéro Beilstein :
2820605
Numéro MDL:
MFCD00057597
Code UNSPSC :
41116107
ID de substance PubChem :
329818446
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

niclosamide

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

Oc1ccc(Cl)cc1C(=O)Nc2ccc(cc2Cl)[N+]([O-])=O

InChI

1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)

Clé InChI

RJMUSRYZPJIFPJ-UHFFFAOYSA-N

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Niclosamide (anhydrous) EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Masanori Ono et al.
Fertility and sterility, 101(5), 1441-1449 (2014-02-19)
To assess the effect of three WNT/β-catenin pathway inhibitors-inhibitor of β-catenin and TCF4 (ICAT), niclosamide, and XAV939-on the proliferation of primary cultures of human uterine leiomyoma cells. Prospective study of human leiomyoma cells obtained from myomectomy or hysterectomy. University research
K Ketola et al.
British journal of cancer, 106(1), 99-106 (2012-01-05)
We have shown that a sodium ionophore monensin inhibits prostate cancer cell growth. A structurally related compound to monensin, salinomycin, was recently identified as a putative cancer stem cell inhibitor. The growth inhibitory potential of salinomycin was studied in a
Wenyan Lu et al.
PloS one, 6(12), e29290-e29290 (2011-12-24)
The Wnt/β-catenin signaling pathway is important for tumor initiation and progression. The low density lipoprotein receptor-related protein-6 (LRP6) is an essential Wnt co-receptor for Wnt/β-catenin signaling and represents a promising anticancer target. Recently, the antihelminthic drug, niclosamide was found to
Jing-Xuan Pan et al.
Chinese journal of cancer, 31(4), 178-184 (2012-01-13)
Niclosamide, an oral antihelminthic drug, has been used to treat tapeworm infection for about 50 years. Niclosamide is also used as a molluscicide for water treatment in schistosomiasis control programs. Recently, several groups have independently discovered that niclosamide is also
Jones Gyamfi et al.
Scientific reports, 9(1), 11336-11336 (2019-08-07)
The microenvironment of breast cancer comprises predominantly of adipocytes. Adipocytes drive cancer progression through the secretion adipocytokines. Adipocytes induce epithelial mesenchymal transition of breast cancer cells through paracrine IL-6/Stat3 signalling. Treatment approaches that can target adipocytes in the microenvironment and
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