475878

(+)-MK 801 Maleate

A highly potent, selective, and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA-associated ion channel, thus preventing Ca²⁺ flux.

• Synonyme(s) : (+)-MK 801 Maleate, (5R,10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-10-imine, Maleate, Dizocilpine Maleate, NMDA Antagonist I
• Formule empirique (notation de Hill): C₁₆H₁₅N · xC₄H₄O₄
• Numéro CAS: 77086-22-7
• Poids moléculaire : 221.30 (free base basis)
• Numéro MDL: MFCD00082465
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated
• Couleur: white
• Solubilité: water: 3 mg/mL; ethanol: soluble
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-,16+;/m1./s1
• Clé InChI: QLTXKCWMEZIHBJ-PJGJYSAQSA-N

Description

Description générale

A highly potent, selective and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA associated ion channel, preventing Ca²⁺ flux. An effective anti-ischemic agent in several animal models. Has been used to develop an in vivo model of NMDA receptor-dependent apoptotic neurodegenerative disease in developing rat brains. Has also been used to develop an in vitro model of NMDA receptor-specific Ca²⁺ entry induced seizures.

A highly potent, selective, and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA-associated ion channel, thus preventing Ca²⁺ flux. An effective anti-ischemic agent in several animal models. Has been used to develop an in vivo model of NMDA receptor-dependent apoptotic neurodegenerative disease in developing rat brains. Has also been used to develop an in vitro model of NMDA receptor-specific Ca²⁺ entry induced seizures.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
NMDA receptor

Reversible: no

Avertissement

Toxicity: Standard Handling (A)

Notes préparatoires

Stock solutions in water may require warming and vigorous stirring to achieve complete solubilization.

Reconstitution

Following reconstitution in water refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Aqueous stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.

Autres remarques

Ikonomidou, C., et al. 1999. Science 283, 70.
DeLorenzo, R.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14482.
Woodruff, G.N., et al. 1987. Neuropharmacology 26, 903.
Wong, E.H.F., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 7104.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable