422686
Kininogen, High Molecular Weight, Single Chain, Human Plasma
Native, single chain, high molecular weight Kininogen from human plasma.
Synonyme(s) :
High molecular weight kininogen
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About This Item
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.28
Produits recommandés
Niveau de qualité
Pureté
≥95% (SDS-PAGE)
Forme
liquid
Fabricant/nom de marque
Calbiochem®
Conditions de stockage
OK to freeze
avoid repeated freeze/thaw cycles
Conditions d'expédition
wet ice
Température de stockage
−70°C
Description générale
Native, single chain, high molecular weight Kininogen from human plasma. Non-enzymatic cofactor of the contact activation system. Links prekallikrein to negatively charged surfaces, thereby allowing activation to kallikrein by surface-bound Factor a-XIIa. Also circulates in plasma in complex with Factor XI, that may play a role in the activation of Factor XI to Factor XIa by Factor α-XIIa. Serves as a source of bradykinin, a potent vasoactive peptide important in hypotension studies.
Native, single chain, high molecular weight Kininogen from human plasma. Nonenzymatic cofactor of the contact activation system. Links prekallikrein to negatively charged surfaces, thereby allowing activation to kallikrein by surface-bound Factor α-XIIa. Also circulates in plasma in complex with Factor XI and may play a role in the activation of Factor XI to Factor XIa by Factor α-XIIa. Serves as a source of bradykinin, a potent vasoactive peptide important in hypotension studies.
Conditionnement
Please refer to vial label for lot-specific concentration.
Avertissement
Toxicity: Standard Handling (A)
Forme physique
In 150 mM NaCl, 4 mM sodium acetate buffer, pH 5.3.
Notes préparatoires
Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Reconstitution
Following initial thaw, aliquot and freeze (-70°C).
Autres remarques
Weisel, J.W., et al. 1994. J. Biol. Chem. 269, 10100.
Informations légales
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Rasmus Pihl et al.
Science advances, 7(2) (2021-02-02)
Inter-α-inhibitor heavy chain 4 (ITIH4) is a poorly characterized plasma protein that is proteolytically processed in multiple pathological conditions. However, no biological function of ITIH4 has been identified. Here, we show that ITIH4 is cleaved by several human proteases within
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
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