902683

BocNH-PEG5-acid

• Synonyme(s) : 2,2-Dimethyl-4-oxo-3,8,11,14,17,20-hexaoxa-5-azadocosan-22-oic acid, Boc-NH-PEG5-CH₂COOH
• Formule empirique (notation de Hill): C₁₇H₃₃NO₉
• Numéro CAS: 890152-41-7
• Poids moléculaire : 395.45
• Code UNSPSC : 12352106
• Nomenclature NACRES : NA.22

Propriétés

• Forme: liquid
• Capacité de réaction: reaction type: Pegylations
• Pertinence de la réaction: reagent type: cross-linking reagent
• Groupe fonctionnel: Boc; amine; carboxylic acid
• Température de stockage: −20°C
• Chaîne SMILES: OC(COCCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O

Description

Application

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. BocNH-PEG5-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Informations légales

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable