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1463600

USP

Nifedipinnitrophenylpyridin-Analogon

United States Pharmacopeia (USP) Reference Standard

Synonym(e):

Oxidiertes Nifedipin, 2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridincarbonsäure-dimethylester

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About This Item

Empirische Formel (Hill-System):
C17H16N2O6
CAS-Nummer:
67035-22-7
Molekulargewicht:
344.32
MDL-Nummer:
MFCD00153847
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329750559
NACRES:
NA.24

Qualität

pharmaceutical primary standard

API-Familie

nifedipine

Hersteller/Markenname

USP

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

SMILES String

COC(=O)c1c(C)nc(C)c(C(=O)OC)c1-c2ccccc2[N+]([O-])=O

InChI

1S/C17H16N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8H,1-4H3

InChIKey

UMQHJQGNGLQJPF-UHFFFAOYSA-N

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Verwandte Kategorien

Anwendung

Nifedipine Nitrophenylpyridine Analog USP Reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Nifedipine Capsules
  • Nifedipine
  • Nifedipine Extended-Release Tablets

Biochem./physiol. Wirkung

CYP3A4 Nifedipin Metabolit. Nifedipin (Ausgangssubstanz) ist ein antianginal und blutdrucksenkendes Mittel.

Hinweis zur Analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Sonstige Hinweise

Sales restrictions may apply.

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N0750010

Nifedipin-Unreinheit A, European Pharmacopoeia (EP) Reference Standard

N0750015

Nifedipin-Unreinheit B, European Pharmacopoeia (EP) Reference Standard

1463701

Nifedipinnitrosophenylpyridin-Analogon, United States Pharmacopeia (USP) Reference Standard

PHR1290

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Nifedipin, British Pharmacopoeia (BP) Reference Standard

BP866

Dimethyl-2,6-dimethyl-4-(2-nitrosophenyl)-3,5-Pyridindicarboxylat, British Pharmacopoeia (BP) Reference Standard

Piktogramme

Corrosion
GHS05

Signalwort

Danger

H-Sätze

H318

Gefahreneinstufungen

Eye Dam. 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Wenzhan Yang et al.
Current drug discovery technologies, 5(2), 129-139 (2008-08-05)
This study reports the use of para-sulphonato calix[8]arene to produce stable complexes with improved bioavailability for nifedipine, a calcium-channel blocker that is practically insoluble in water. Thermal analysis and electrospray ionisation mass spectroscopy confirmed that nifedipine formed complexes with the
Tsai-Shin Chiang et al.
PloS one, 9(4), e94885-e94885 (2014-04-16)
Human hepatoma cell lines are commonly used as alternatives to primary hepatocytes for the study of drug metabolism in vitro. However, the phase I cytochrome P450 (CYP) enzyme activities in these cell lines occur at a much lower level than
Camille C Savary et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(8), 1235-1240 (2014-05-17)
Humans are usually exposed to several pesticides simultaneously; consequently, combined actions between pesticides themselves or between pesticides and other chemicals need to be addressed in the risk assessment. Many pesticides are efficient activators of pregnane X receptor (PXR) and/or constitutive
Yohei Kosugi et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(4), 345-352 (2014-11-12)
1. The purpose of this study was to clarify species differences in the heteroactivation of CYP3A substrates by efavirenz, which is known from clinical studies to activate midazolam 1'-hydroxylation, and to assess the feasibility of an animal model. 2. In monkey and
Yoshihiko Shimokawa et al.
Biological & pharmaceutical bulletin, 37(11), 1727-1735 (2014-11-05)
Delamanid is a new drug for the treatment of multidrug-resistant tuberculosis. Individuals who are co-infected with human immunodeficiency virus and Mycobacterium tuberculosis may require treatment with a number of medications that might interact significantly with the CYP enzyme system as
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