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Merck

1066009

USP

Betamethason

United States Pharmacopeia (USP) Reference Standard

Synonym(e):

9α-Fluor-11β,17α,21-trihydroxy-16β-methylpregna-1,4-dien-3,20-dion, 9α-Fluor-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadien-3,20-dion, 9α-Fluor-16β-methylprednisolon

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About This Item

Empirische Formel (Hill-System):
C22H29FO5
CAS-Nummer:
Molekulargewicht:
392.46
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

Biologische Quelle

synthetic

Qualität

pharmaceutical primary standard

Agentur

USP

Dampfdruck

<0.0000001 kPa ( 25 °C)

API-Familie

betamethasone

Verpackung

pkg of 200 mg

Hersteller/Markenname

USP

Farbe

white to off-white

mp (Schmelzpunkt)

235-237 °C (lit.)
447.8-473 °F (231—245°C; decomposes)

Löslichkeit

acetone: sparingly soluble
chloroform: very slightly soluble
ethanol: sparingly soluble
ether: very slightly soluble
methanol: sparingly soluble
water: insoluble

Dichte

0.305 g/cm3 at 25 °C (77°F)

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

SMILES String

[H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1

InChIKey

UREBDLICKHMUKA-DVTGEIKXSA-N

Angaben zum Gen

human ... NR3C1(2908)

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Allgemeine Beschreibung

Betamethasone, a synthetic glucocorticoid, belongs to the corticosteroid family of active pharmaceutical ingredients (APIs).
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Betamethasone USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Betamethasone Acetate
  • Betamethasone Oral Solution
  • Betamethasone Valerate Cream
  • Betamethasone Valerate Lotion
  • Betamethasone Valerate Ointment
  • Dexamethasone

Hinweis zur Analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Sonstige Hinweise

Sales restrictions may apply.

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Piktogramme

Health hazard

Signalwort

Danger

H-Sätze

Gefahreneinstufungen

Repr. 1B - STOT RE 2

Zielorgane

Liver,Kidney,Endocrine system

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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Kunden haben sich ebenfalls angesehen

Betamethasone
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 44(1), 541-541 (2020)
Simultaneous determination of dexamethasone and betamethasone in pharmaceuticals by reversed-phase HPLC
Santos-Montes A, et al.
Chromatographia, 39(9-10), 539-542 (1994)
Analysis of betamethasone and its organic esters in pharmaceutical products
Graham RE, et al.
Journal of Pharmaceutical Sciences, 67(3), 360-363 (1978)
Extraction-spectrophotometric method for the determination of betamethasone in pure form and in pharmaceutical formulations
Amin AS and Issa YM
Analytical Letters, 30(1), 69-78 (1997)
Development and validation of a stability-indicating RP-HPLC method for assay of betamethasone and estimation of its related compounds
Fu Q, et al.
Journal of Pharmaceutical and Biomedical Analysis, 51(3), 617-625 (2010)

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