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Z4527

Sigma-Aldrich

Zopolrestat

≥98% (HPLC)

Synonym(e):

3,4-Dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl]methyl]-1-phthalazineacetic acid, Alond, CP-73850, Xedia

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About This Item

Empirische Formel (Hill-System):
C19H12F3N3O3S
CAS-Nummer:
110703-94-1
Molekulargewicht:
419.38
MDL-Nummer:
MFCD00865476
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329831615
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Farbe

off-white to light brown

Löslichkeit

DMSO: ≥20 mg/mL

Lagertemp.

2-8°C

SMILES String

OC(=O)CC1=NN(Cc2nc3cc(ccc3s2)C(F)(F)F)C(=O)c4ccccc14

InChI

1S/C19H12F3N3O3S/c20-19(21,22)10-5-6-15-14(7-10)23-16(29-15)9-25-18(28)12-4-2-1-3-11(12)13(24-25)8-17(26)27/h1-7H,8-9H2,(H,26,27)

InChIKey

BCSVCWVQNOXFGL-UHFFFAOYSA-N

Verwandte Kategorien

Biochem./physiol. Wirkung

Zopolrestat is an inhibitor of Aldose Reductase.
Zopolrestat is an inhibitor of Aldose Reductase. AR family members AKR1B1 and AKR1B10 have additionally been shown to play roles in inflammation and cancer.

Leistungsmerkmale und Vorteile

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301,H413

Gefahreneinstufungen

Acute Tox. 3 Oral - Aquatic Chronic 4

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000366807
0000366807
090M4628V
017M4752V
090M4628

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Cornelia Koch et al.
Biochimica et biophysica acta, 1810(9), 879-887 (2011-06-21)
Flexibility is a common feature of proteins. For human aldose reductase, a variety of conformers have been observed in crystalline complexes with different inhibitors. A study of crystal structures and isothermal titration calorimetry was performed on wild type and mutated
Umesh C S Yadav et al.
Investigative ophthalmology & visual science, 48(10), 4634-4642 (2007-09-28)
The purpose of the present study was to elucidate the role of the polyol pathway enzyme aldose reductase (AR) in the mediation of ocular inflammation in a rat model of endotoxin-induced uveitis (EIU). EIU was induced by a subcutaneous injection
Holger Steuber et al.
Journal of molecular biology, 363(1), 174-187 (2006-09-06)
In structure-based drug design, accurate crystal structure determination of protein-ligand complexes is of utmost importance in order to elucidate the binding characteristics of a putative lead to a given target. It is the starting point for further design hypotheses to
Brian F Johnson et al.
Diabetes care, 27(2), 448-454 (2004-01-30)
The goal of this study was to determine whether treatment with an aldose reductase inhibitor (ARI) has beneficial effects on asymptomatic cardiac abnormalities in diabetic patients with neuropathy. Diabetic subjects with neuropathy (n = 81) with either a low diastolic
Hirdesh Kumar et al.
Journal of molecular modeling, 18(5), 1791-1799 (2011-08-13)
Aldose reductase (ALR2) plays a vital role in the etiology of long-term diabetic microvascular complications (DMCs) such as retinopathy, nephropathy and neuropathy. It initializes the polyol pathway and under hyperglycemic conditions, catalyzes the conversion of glucose into sorbitol in the
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