W4016

Wedelolacton

≥98% (HPLC), powder

• Synonym(e): 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-on, 7-Methoxy-5,11,12-trihydroxy-cumestan
• Empirische Formel (Hill-System): C₁₆H₁₀O₇
• CAS-Nummer: 524-12-9
• Molekulargewicht: 314.25
• MDL-Nummer: MFCD07778564
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24724667
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to brown
• Löslichkeit: DMSO: 10 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: COc1cc(O)c-2c(OC(=O)c3c-2oc4cc(O)c(O)cc34)c1
• InChI: 1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3
• InChIKey: XQDCKJKKMFWXGB-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Irreversible inhibitor of IKKα and β kinase activity (IC₅₀ < 10 μM). Wedelolactone has no effects on p38 MAP kinase or Akt.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves