465119

Baicalein

98%

• Synonym(e): 5,6,7-Trihydroxy-flavon
• Empirische Formel (Hill-System): C₁₅H₁₀O₅
• CAS-Nummer: 491-67-8
• Molekulargewicht: 270.24
• Beilstein: 272683
• MDL-Nummer: MFCD00017459
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24870246
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: 98%
• Form: solid
• mp (Schmelzpunkt): 256-271 °C (lit.)
• Funktionelle Gruppe: ketone; phenyl
• SMILES String: Oc1cc2OC(=CC(=O)c2c(O)c1O)c3ccccc3
• InChI: 1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
• InChIKey: FXNFHKRTJBSTCS-UHFFFAOYSA-N
• Angaben zum Gen: mouse ... Hexa(15211) ; rat ... Alox15(81639) , Alox5(25290)

Beschreibung

Allgemeine Beschreibung

Baicalein, a flavonoid, is a xanthine oxidase inhibitor. Anti-inflammatory effects of baicalein in peripheral human leukocytes has been studied.

Anwendung

Baicalein was used in a study to investigate the in vitro quantitative inhibition of lipoxygenase.

Biochem./physiol. Wirkung

The flavonoid component of Nepalese and Sino-Japanese crude drugs. Baicalein, a major flavone of Scutellariae baicalensis, inhibits the 12-lipoxygenase (12-LOX) pathway of arachidonic acid metabolism, which inhibits cancer cell proliferation and induces apoptosis.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves