U4133

URB597

≥98% (HPLC), powder

• Synonym(e): Cyclohexylcarbamic acid 3´-carbamoyl-biphenyl-3-yl ester
• Empirische Formel (Hill-System): C₂₀H₂₂N₂O₃
• CAS-Nummer: 546141-08-6
• Molekulargewicht: 338.40
• MDL-Nummer: MFCD05863934
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329827629
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white
• Löslichkeit: DMSO: soluble ~14 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: NC(=O)c1cccc(c1)-c2cccc(OC(=O)NC3CCCCC3)c2
• InChI: 1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24)
• InChIKey: ROFVXGGUISEHAM-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

URB597 binds to active sites of fatty acid amide hydrolases and inhibits their activity. URB597 alters expression of tyrosine hydroxylase and interacts with abnormal-cannabidiol (Abn-CBD) and peroxisome proliferator-activated receptors (PPARs). URB597 elicits antinociception property via cannabinoid receptor by maintaining endocannabinoid anandamide (AEA) levels. URB597 reduces abnormal hyperactivity in neurons and could be for treatment of seizures and improving synaptic plasticity.

Biochem./physiol. Wirkung

Potent, selective fatty acid amide hydrolase (FAAH) inhibitor.

Angaben zur Herstellung

URB597 is soluble in DMSO at a concentration that is approximately 14 mg/ml.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: Eyeshields, Gloves