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U101

Sigma-Aldrich

5-Methylurapidil

solid

Synonym(e):

5-Methyl-6[[3-[4-(2-methoxyphenyl)-1-piperazinyl]­propyl]­amino]-1,3-dimethyluracil

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About This Item

Empirische Formel (Hill-System):
C21H31N5O3
CAS-Nummer:
34661-85-3
Molekulargewicht:
401.50
MDL-Nummer:
MFCD00078602
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24277800
NACRES:
NA.77

Form

solid

Qualitätsniveau

100

Farbe

white

Löslichkeit

H2O: 0.4 mg/mL
0.1 M HCl: 3.8 mg/mL

SMILES String

Cl[H].COc1ccccc1N2CCN(CCCNC3=C(C)C(=O)N(C)C(=O)N3C)CC2

InChI

1S/C21H31N5O3.ClH/c1-16-19(23(2)21(28)24(3)20(16)27)22-10-7-11-25-12-14-26(15-13-25)17-8-5-6-9-18(17)29-4;/h5-6,8-9,22H,7,10-15H2,1-4H3;1H

InChIKey

WAZDYFHTLYHMKO-UHFFFAOYSA-N

Angaben zum Gen

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

Anwendung

5-Methylurapidil has been used for competitive binding in radioligand binding assays.

Biochem./physiol. Wirkung

Selective α1A-adrenoceptor antagonist; antihypertensive.

Leistungsmerkmale und Vorteile

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Angaben zur Herstellung

5-Methylurapidil is soluble in water at 0.4 mg/ml and is also soluble in 0.1 M HCl at 3.8 mg/ml.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

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Z Huang et al.
Journal of dental research, 85(3), 251-256 (2006-02-25)
alpha(1)-Adrenoceptor has been discovered to exist in many human tissues and mediates important physiological functions. The purpose of this study was to detect the expression, distribution, and function of alpha(1)-adrenoceptor subtypes in human submandibular glands. alpha(1A)- and alpha(1B)-Adrenoceptor mRNAs were
Kim Davenport et al.
BJU international, 98(3), 651-655 (2006-08-24)
To compare the in vitro human ureteric muscle response to calcium-channel and alpha-adrenoceptor antagonists, to determine the promoting factor for stone passage. Clinical trials suggest that stone passage in renal colic can be promoted by ureteric relaxation using these agents
Rocío Alcántara-Hernández et al.
Biochimica et biophysica acta, 1864(12), 2378-2388 (2017-09-11)
In LNCaP cells that stably express α
Abdul H Khan et al.
European journal of pharmacology, 569(1-2), 110-118 (2007-06-15)
This study investigated whether the alpha(1)-adrenoceptor subtype(s) mediating the vasoconstrictor actions of the renal sympathetic nerves were altered in rats with cisplatin-induced renal failure. Male Wistar Kyoto rats were used and half received cisplatin (5 mg/kg i.p.) to induce renal
D W Gil et al.
British journal of pharmacology, 153(4), 769-774 (2007-08-19)
The most common preclinical models of neuropathic pain involve surgical ligation of sensory nerves, which is especially difficult in mice. Transient models of chemically sensitized allodynia are potentially useful for rapidly characterizing the analgesic profile of compounds and conducting mechanistic
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