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T2376

Sigma-Aldrich

L-Thyroxin

≥98% (HPLC)

Synonym(e):

3,3′,5,5′′-Tetraiod-L-thyronin, 3-[4-(4-Hydroxy-3,5-diiodphenoxy)-3,5-diiodphenyl]-L-alanin, T4

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About This Item

Lineare Formel:
HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H
CAS-Nummer:
51-48-9
Molekulargewicht:
776.87
Beilstein:
2228515
EG-Nummer:
200-101-1
MDL-Nummer:
MFCD00002595
UNSPSC-Code:
51111800
PubChem Substanz-ID:
24900033
NACRES:
NA.32

Biologische Quelle

synthetic

Qualitätsniveau

200

Sterilität

non-sterile

Assay

≥98% (HPLC)

Form

powder

Methode(n)

cell culture | mammalian: suitable

mp (Schmelzpunkt)

223 °C (dec.) (lit.)

Löslichkeit

4 M NH4OH in methanol: 50 mg/mL, clear to hazy, yellow

Versandbedingung

ambient

Lagertemp.

room temp

SMILES String

N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1

InChIKey

XUIIKFGFIJCVMT-LBPRGKRZSA-N

Angaben zum Gen

human ... THRA(7067) , THRB(7068) , TTR(7276)
mouse ... Cnr2(12802)
rat ... Cnr1(25248)

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Anwendung

L-Thyroxine was used to study the light-induced hormone conversion of T4 to T3 in regulation of photoperiodic response of gonads in Japanese quail. The product was used as a test compound for studying the impact of numerous hormones on the surface morphology of rat testicular cells in culture.

Biochem./physiol. Wirkung

L-Thyroxine is an iodine containing hormone produced from thyroglobulin in the thyroid follicular cells. L-Thyroxine reduces total cholesterol level, low-density lipoprotein cholesterol as well as waist to hip ratio in subclinical hypothyroidism pateints. Hence, facilitates in improving cardiovascular risk factor as well as can enhance symptoms of tiredness.
L-Thyroxine (T4) and triiodo-L-thyronine (T3) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Angaben zur Herstellung

L-Thyroxine dissolves in 4M ammonium hydroxide in Methanol at 50 mg/ml to yield a clear to hazy yellow to dark yellow solution.

Ähnliches Produkt

Produkt-Nr.
Beschreibung
Preisangaben

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H372

Gefahreneinstufungen

STOT RE 1

Zielorgane

Thyroid,Cardio-vascular system,Kidney

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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3,3′,5′-Triiodo-L-thyronine-13C6 (reverse T3-13C6) 100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

T-078

3,3′,5′-Triiodo-L-thyronine-13C6 (reverse T3-13C6)

Takashi Yoshimura et al.
Nature, 426(6963), 178-181 (2003-11-14)
Reproduction of many temperate zone birds is under photoperiodic control. The Japanese quail is an excellent model for studying the mechanism of photoperiodic time measurement because of its distinct and marked response to changing photoperiods. Studies on this animal have
Tom Sarraude et al.
PeerJ, 8, e10175-e10175 (2020-10-23)
Maternal thyroid hormones (THs) are known to be crucial in embryonic development in humans, but their influence on other, especially wild, animals remains poorly understood. So far, the studies that experimentally investigated the consequences of maternal THs focused on short-term
J C Hutson
The American journal of anatomy, 151(1), 55-69 (1978-01-01)
The purpose of this investigation was to study the effects of various hormones on the surface morphology of 20-day-old rat testicular cells in culture. Aggregates containing primarily Sertoli cells and germinal cells were obtained by enzymatic digestion. The surface morphology
Turan Demircan et al.
Data in brief, 29, 105179-105179 (2020-02-15)
The presented data article reports protein expression profiles during a time course of limb regeneration in the highly regenerative neotenic and regeneration-deficient metamorphic axolotl (Ambystoma mexicanum). A protein database was first generated from transcriptome data, which was used concomitantly with
Salman Razvi et al.
The Journal of clinical endocrinology and metabolism, 92(5), 1715-1723 (2007-02-15)
Subclinical hypothyroidism (SCH) is defined as raised serum TSH levels with circulating thyroid hormones within the reference range. It is uncertain whether treatment of SCH with L-thyroxine improves cardiovascular (CV) risk factors and quality of life. The objective of the
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