SRP8026

Annexin V human

recombinant, expressed in E. coli, GST tagged, ≥95% (SDS-PAGE)

• Synonym(e): Annexin A5, Calphobindin I, EC 2.7.1.23, Endonexin II, Placental anticoagulantprotein I
• UNSPSC-Code: 12352200
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: human
• Rekombinant: expressed in E. coli
• Markierung: GST tagged
• Assay: ≥95% (SDS-PAGE)
• Form: lyophilized
• Mol-Gew.: ~52 kDa
• Verpackung: pkg of 100 μg
• Lagerbedingungen: avoid repeated freeze/thaw cycles
• Methode(n): activity assay: suitable
• Farbe: white
• UniProt-Hinterlegungsnummer: P08758
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Angaben zum Gen: human ... ANXA5(308)

Beschreibung

Allgemeine Beschreibung

Annexin V is a member of the annexin family of calcium and membrane-binding proteins that have anticoagulatory and anti-inflammatory properties. The encoded protein is 320 amino acid long and is folded into four domains, each having five α-helices, forming a superhelical globular structure. The ANX5 gene is mapped to human chromosome 4q26-q28 and spans a length of 28kb containing 13 exons and 12 introns.

Anwendung

Annexin V has been used to examine phosphorylation activity of ChaK1 (channel-kinase 1).

Biochem./physiol. Wirkung

Annexins are a family of water-soluble proteins that bind to membranes and phospholipids in a calcium-dependent manner. They participate in several cellular functions, such as membrane fusion and cytoskeletal interaction. Annexin V is a potent anticoagulant and serves as a voltage-gated calcium channel when bound to membrane in vitro. It is found to inhibit phospholipase A2 and protein kinase C.

Physikalische Form

Lyophilized from PBS, pH 7.4.

Rekonstituierung

Reconstitute with 100 μL deionized water.

Sonstige Hinweise

Recombinant human annexin V fused to a GST-tag.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable