SRP6056

Dipeptidylpeptidase human

recombinant, expressed in Hi-5 Insect cells, ≥95% (SDS-PAGE)

• Synonym(e): ADABP, Adenosine deaminase complexing protein 2, CD26, DPPIV, TP103
• UNSPSC-Code: 12352204
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: human
• Rekombinant: expressed in Hi-5 Insect cells
• Assay: ≥95% (SDS-PAGE)
• Form: liquid
• Mol-Gew.: 86.4 kDa
• Verpackung: pkg of 10 μg
• Konzentration: 0.5 mg/mL
• NCBI-Hinterlegungsnummer: P27487
• UniProt-Hinterlegungsnummer: P27487
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Angaben zum Gen: human ... DPP4(1803)

Beschreibung

Allgemeine Beschreibung

DPP4 is a serine exopeptidase and complex enzyme that is expressed on the surface of most cell types as an intrinsic membrane glycoprotein that cleaves X-proline dipeptides from the N-terminus of polypeptides and plays a role in t-cell activation. DPP4 is associated with intracellular signal transduction, apoptosis and involved in tumor biology. There are at least 63 substrates which can bind specifically to DPP4 enzyme including growth factors, chemokines, neuro peptides. Furthermore, DPP4 plays a major role in glucose metabolism by cleaving incretins such as glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). DPP4 Human Recombinant is a single, glycosylated polypeptide chain containing 746 amino acids (aa 39-766) with a C-terminal His-tag and is purified using conventional chromatography techniques.

Physikalische Form

0.5 mg/mL; Sterile filtered solution containing 20 mM Tris-HCl buffer pH 8.0,100 mM NaCl, 1 mM EDTA and 10 % glycerol.

Angaben zur Herstellung

Centrifuge the vial prior to opening.

Sonstige Hinweise

ADP-SRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP-SGRLVPRGSHHHHHH

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable