SML3908

SLU-PP-332

≥98% (HPLC)

• Synonym(e): (E)-4-Hydroxy-N′(naphthalen-2-ylmethylene)benzohydrazide, 4-Hydroxybenzoic acid 2-(2-naphthalenylmethylene)hydrazide, ERR pan-Agonist 332, SR9861
• Empirische Formel (Hill-System): C₁₈H₁₄N₂O₂
• CAS-Nummer: 303760-60-3
• Molekulargewicht: 290.32
• MDL-Nummer: MFCD00595076
• UNSPSC-Code: 51111800
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear (Warmed)
• Lagertemp.: 2-8°C
• SMILES String: OC1=CC=C(C=C1)C(N/N=C/C2=CC3=C(C=C2)C=CC=C3)=O
• InChIKey: RNZIMBFHRXYRLL-XDHOZWIPSA-N

Beschreibung

Biochem./physiol. Wirkung

Non-toxic pan ERRα/β/γ agonist with significant ERRα activity that acts as an exercise mimetic.



SLU-PP-332 is a non-toxic pan ERRα/β/γ (estrogen receptor-related receptors α/β/γ) agonist with significant ERRα activity (EC50 = 98, 230 & 430 nM against ERRα, ERRβ & ERγ) and acts as an exercise mimetic. SLU-PP-332 displays selectivity over ERα, ERβ and several other closely related nuclear receptors. It induces Ddit4 expression and enhances mitochondrial respiration in C2C12 myocytes (10 µM) and exercise endurance in mice (50 mg/kg bid, ip) in an ERRα-dependent manner.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable