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SML3434

Sigma-Aldrich

Erucin

≥98% (HPLC)

Synonym(e):

(4-Isothiocyanatobutyl)(methyl)sulfane; 4-(Methylthio)butyl isothiocyanate, 1-Isothiocyanato-4-(methylthio)butane, ERU, MTBITC

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About This Item

Empirische Formel (Hill-System):
C6H11NS2
CAS-Nummer:
4430-36-8
Molekulargewicht:
161.29
MDL-Nummer:
MFCD01656048
UNSPSC-Code:
41121801
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

oil

Farbe

colorless to yellow

Lagertemp.

-10 to -25°C

SMILES String

CSCCCCN=C=S

InChI

1S/C6H11NS2/c1-9-5-3-2-4-7-6-8/h2-5H2,1H3

InChIKey

IHQDGXUYTSZGOG-UHFFFAOYSA-N

Biochem./physiol. Wirkung

Erucin (MTBITC) is an orally available, hydrogen sulfide (H2S)-releasing isothiocyanate (ITC) derived from glucoerucin found in the Brassicaceae family of plants (rocket salads), including arugula (Eruca sativa Mill.). Erucin is also formed in vivo through the reduction of sulforaphane, an ITC found in broccoli. Erucin displays neuroprotective, antioxidant, and anticancer efficacy in vitro and in vivo by inducing intracellular reactive oxygen species (ROS) production and Nrf2 activaiton.

Piktogramme

Corrosion
GHS05

Signalwort

Danger

H-Sätze

H314

Gefahreneinstufungen

Eye Dam. 1 - Skin Corr. 1B

Lagerklassenschlüssel

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Mohammed Sani Jaafaru et al.
Nutrients, 10(5) (2018-05-09)
Crucifer vegetables, Brassicaceae and other species of the order Brassicales, e.g., Moringaceae that are commonly consumed as spice and food, have been reported to have potential benefits for the treatment and prevention of several health disorders. Though epidemiologically inconclusive, investigations
Piman Pocasap et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 101, 698-709 (2018-03-10)
The structure of the isothiocyanates (ITCs)-erucin, sulforaphane, erysolin, sulforaphene, and phenethyl isothiocyanate-were assessed as well as their respective in vitro anticancer activity on the hepatocellular carcinoma cell line HepG2. All of these ITCs induced both apoptotic and necrotic cell death.
Valentina Citi et al.
Phytotherapy research : PTR, 33(3), 845-855 (2019-01-12)
Plants of the Brassicaceae family are well-known for containing the glucosinolate myrosinase system, which is able to release isothiocyanates after plant biotic and abiotic lesions. Erucin (ERU; 1-isothiocyanato-4-(methylthio)-butane), an isothiocyanate particularly abundant in arugula (Eruca sativa Mill., Eruca vesicaria L.
Fabiana Morroni et al.
Journal of agricultural and food chemistry, 66(4), 856-865 (2018-01-09)
Several studies suggest that an increase of glutathione (GSH) through activation of the transcriptional nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in the dopaminergic neurons may be a promising neuroprotective strategy in Parkinson's disease (PD). Among Nrf2 activators, isothiocyanate sulforaphane (SFN)
Umme Salma et al.
Journal of ethnopharmacology, 224, 409-420 (2018-06-19)
Eruca sativa Mill., (Brassicaceae) is a popular remedy for the treatment of hypertension in Pakistan. However, direct effect of the extract and its fractions on blood pressure and vascular tone are unknown. This investigation was aimed to explore the pharmacological
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