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SML2392

Sigma-Aldrich

DREADD Agonist 21 dihydrochloride

≥98% (HPLC), powder, DREADD agonist

Synonym(e):

11-(1-piperazinyl)-5H-Dibenzo[b,e][1,4]diazepine dihydrochloride, 11-(Piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine; 11-Piperazinyldibenzo[b,e][1,4]diazepine dihydrochloride, Compound 21 dihydrochloride

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About This Item

Empirische Formel (Hill-System):
C17H18N4 · 2HCl
CAS-Nummer:
56296-18-5
Molekulargewicht:
351.27
MDL-Nummer:
MFCD25121806
UNSPSC-Code:
12352200
NACRES:
NA.77

Produktbezeichnung

DREADD Agonist 21 dihydrochloride, ≥98% (HPLC)

Assay

≥98% (HPLC)

Form

powder

Lagerbedingungen

desiccated

Farbe

yellow to brown

Löslichkeit

H2O: 2 mg/mL, clear

Lagertemp.

−20°C

SMILES String

C1(C=CC=C2)=C2C(N3CCNCC3)=NC(C=CC=C4)=C4N1

InChI

1S/C17H18N4/c1-2-6-14-13(5-1)17(21-11-9-18-10-12-21)20-16-8-4-3-7-15(16)19-14/h1-8,18-19H,9-12H2

InChIKey

JCBYXNSOLUVGTF-UHFFFAOYSA-N

Biochem./physiol. Wirkung

Compound 21 is a potent designer drug with full agonist activity toward human hM3Dq (EC50 = 1.7 nM by cell-based Ca2+ mobilization assay), a human M3 muscarinic receptor (M3R)-based Gq (M3Dq) DREADD (Designer Receptors Exclusively Activated by Designer Drugs), displaying little activity toward muscarinic acetylcholine receptor M3 (30% M3 activation at 10 μM) and reduced affinity toward H1, 5HT2A, 5HT2C, α1A receptor (fold selectivity = 3.5, 40, 100, 165, respectively). Note: the DREADD hM3Dq exhibits M3 biological activity, but is insensitive to the endogenous ligand acetylcholine (ACh).

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000399396
0000399394
0000318822
0000399394
0000399396

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