SML1744

A-971432

≥95% (HPLC)

• Synonym(e): 1-(4-(3,4-Dichlorobenzyloxy)benzyl)azetidine-3-carboxylic acid
• Empirische Formel (Hill-System): C₁₈H₁₇Cl₂NO₃
• CAS-Nummer: 1240308-45-5
• Molekulargewicht: 366.24
• MDL-Nummer: MFCD30182357
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329826050
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 3 mg/mL, clear (warmed)
• Lagertemp.: 2-8°C
• SMILES String: ClC1=CC(COC2=CC=C(CN3CC(C(O)=O)C3)C=C2)=CC=C1Cl
• InChI: 1S/C18H17Cl2NO3/c19-16-6-3-13(7-17(16)20)11-24-15-4-1-12(2-5-15)8-21-9-14(10-21)18(22)23/h1-7,14H,8-11H2,(H,22,23)
• InChIKey: WAAWETUDFSIYSD-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

A-971432 is an orally bioavailable, non-clastogenic, azetidinecarboxylate compound that acts as a highly potent and selective sphingosine-1-phosphate receptor 5 agonist (IC₅₀ = 6 nM/S1P5, 362 nM/S1P1 and >10 μM/S1P3 in a radio-ligand binding assay) without affect the activity of 129 protein kinases (IC₅₀ >10 μM). A-971432 is shown to enhance blood-brain barrier integrity and reverse lipid accumulation and age-related cognitive decline in mice in vivo with good pharmacokinetics (t_1/2  = 5.7 h; C_max = 2,500 ng/ml; AUC = 35,000 ng.h/ml at 10 mg/kg, p.o. in CD1 mice). Likewise, oral gavage showed good plasma exposure and no sign of lymphopenia in rats (10, 30, and 100 mg/kg.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319
• P-Sätze: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable