SML1548

THPN

≥98% (HPLC)

• Synonym(e): 1-(2,4,6-Trihydroxyphenyl)-1-nonanone, 1-(3,4,5-Trihydroxyphenyl)nonan-1-one, CID 3063200
• Empirische Formel (Hill-System): C₁₅H₂₂O₄
• CAS-Nummer: 100079-26-3
• Molekulargewicht: 266.33
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825957
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 25 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: OC1=C(O)C(O)=CC(C(CCCCCCCC)=O)=C1
• InChI: 1S/C15H22O4/c1-2-3-4-5-6-7-8-12(16)11-9-13(17)15(19)14(18)10-11/h9-10,17-19H,2-8H2,1H3
• InChIKey: NVFRHTFJDGAFQS-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

THPN or 1-(3,4,5-Trihydroxyphenyl)nonan-1-one, is a derivative of cytosporone B.

Biochem./physiol. Wirkung

THPN is potent nuclear receptor TR3 (Nur77) antagonist that induces autophagic cell death in melanoma. Co-application of THPN with Akt2 inhibitors significantly represses tumor growth in xenograft mouse model.

Sonstige Hinweise

air sensitive

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable